大环内酯类药物治疗小儿肺炎支原体感染诱发过敏性咳嗽的疗效  

Efficacy of Macrolide Drugs in the Treatment of Allergic Cough Induced by Mycoplasma Pneumoniae Infection in Children

作　　者：袁本泉 YUAN Ben-quan(Department of Pediatrics,Liaocheng Cancer Hospital,Liaocheng 252000,China)

机构地区：[1]聊城市肿瘤医院儿科

出　　处：《中国医药指南》2018年第23期22-23,共2页Guide of China Medicine

摘　　要：目的探讨大环内酯类药物治疗小儿肺炎支原体感染诱发过敏性咳嗽的疗效。方法本次探究将选择2016年1月至2017年12月间在我院治疗肺炎支原体感染诱发过敏性咳嗽的小儿80例作为研究对象,按照小儿的入院时间顺序的奇偶性将小儿分为实验组与对照组,对照组小儿采用常规的治疗方法,实验组小儿在对照组小儿的基础上使用大环内酯类类药物进行治疗,观察两组小儿的治疗有效率、不良反应发生率、3个月后复发率以及3个月后的C-反应蛋白水平、血清总IgE以及外周血嗜酸性粒细胞。结果实验组治疗有效率为97.50%,两组小儿的治疗有效率比较,差异具有统计学意义(χ2=3.914,P=0.048)。实验组复发率为0.00%,对照组复发率为10.0%,两组小儿3个月后复查复发率比较,差异具有统计学意义(χ2=4.211,P=0.040)。实验组小儿不良反应发生率为0.00%,两组小儿不良反应发生率比较,差异不具有统计学意义(χ2=1.013,P=0.314)。实验组小儿的C-反应蛋白水平、血清总IgE以及外周血嗜酸性粒细胞[(11.25±1.56)mg/L、(90.32±31.26)U/mL、(152.25±20.64)×109/L]与对照组相比[(19.25±3.56)mg/L、(109.25±22.59)U/mL、(228.14±30.64)×109/L],差异具有统计学意义(P<0.05)。结论大环内酯类药物治疗小儿肺炎支原体感染诱发过敏性咳嗽效果显著,具有较高的安全性,应在临床中广泛使用。Objective To investigate the efficacy of macrolide drugs in the treatment of allergic cough in children with Mycoplasma pneumoniae infection.Methods This study will select from January 2016 to December 2017 in our hospital for treatment of pneumonia mycoplasma infection induced allergic cough in children 80 cases as the research object,according to the parity of the admission time sequence in children will be children divided into experimental group and control group,the control group of children with conventional treatment,the experimental group used in children macrolide drugs for treatment in the control group based on the treatment of children,the recurrence rate of two groups were observed in children with efficiency,the incidence of adverse reactions,after 3 months and 3 months after C-the levels of C-reactive protein and serum total IgE and peripheral blood eosinophils.Results The effective rate of treatment in the experimental group was 97.50%.The effective rate of treatment in the two groups was statistically significant(χ2=3.914,P=0.048).The recurrence rate in the experimental group was 0%,and the recurrence rate in the control group was 10%.There was a statistically significant difference in the recurrence rate between the two groups after 3 months(χ2=4.211,P=0.040).The incidence of children's adverse reactions in the experimental group was 0%,and the incidence of adverse reactions in the two groups was not statistically significant(χ2=1.013,P=0.314).The experimental groups in the level of C-reactive protein and total serum IgE and peripheral blood eosinophils[(11.25±1.56)mg/L(90.32±31.26)U/mL(152.25±20.64)×109/L]compared with the control group[(19.25±3.56)mg/L(109.25±22.59)U/mL(228.14±30.64)×109/L],the difference was statistically significant(P<0.05).Conclusion Macrolides are effective and safe in the treatment of allergic cough caused by Mycoplasma pneumoniae infection in children.They should be widely used in clinical practice.

关 键 词：大环内酯类 小儿肺炎 支原体感染 过敏性咳嗽 

分 类 号：R725.6[医药卫生—儿科] R441.5[医药卫生—临床医学]