呼吸康复训练联合百令胶囊对矽肺合并COPD患者炎性反应及肺纤维化的影响  

Effect of Respiratory Rehabilitation Training combined with Bailing Capsule on Inflammatory Reaction and Pulmonary Fibrosis in Silicosis Patients Complicated with COPD

作　　者：李淑岷[1] LI Shu-min(Shandong Institute for Occupational Health and Occupational Disease Prevention and Control,Jinan 250002,China)

机构地区：[1]山东省职业卫生与职业病防治研究院

出　　处：《中国医药指南》2018年第23期32-33,35,共3页Guide of China Medicine

摘　　要：目的探讨呼吸康复训练联合百令胶囊对矽肺合并COPD患者炎性反应及肺纤维化的影响。方法选取我院(2015年1月至2017年1月)收治的82例矽肺合并COPD患者为研究对象,所有患者均经临床检查确诊,将本组患者根据治疗方法不同分为两组,对照组41例患者给予百令胶囊治疗,观察组41例患者给予呼吸康复训练联合百令胶囊治疗,对比两组患者治疗前、治疗6个月后、1年后的血清中炎性因子含量和血清中肺纤维化指标含量。结果两组患者治疗前血清中MCP-1、IL-6、IL-8、IL-12、IL-17、IL-18含量对比差异不明显,无统计学意义(P>0.05);治疗后6个月、治疗后1年两组患者血清中MCP-1、IL-6、IL-8、IL-12、IL-17、IL-18含量均明显下降,但观察组患者较对照组更低,差异具有统计学意义(P<0.05)。两组患者治疗前血清中HO-1、ICAM-1、HA、LN、PCⅢ含量对比差异不明显,无统计学意义(P>0.05);治疗后6个月、治疗后1年两组患者血清中HO-1、ICAM-1、HA、LN、PCⅢ含量均明显下降,但观察组患者较对照组更低,差异具有统计学意义(P<0.05)。结论呼吸康复训练联合百令胶囊治疗矽肺合并COPD效果显著,可有效降低患者炎性反应,抑制肺纤维化,值得临床推广。Objective To explore the effect of respiratory rehabilitation training combined with Bailing Capsule on inflammatory reaction and pulmonary fibrosis in silicosis patients complicated with COPD.Methods 82 cases of silicosis with COPD patients admitted in our hospital(January 2015~January 2017)were selected as the research object.All patients were diagnosed by clinical examination.The patients were divided into two groups according to the different treatment methods.41 patients in the control group were given bailing capsule treatment,and 41 patients in the observation group were given respiratory rehabilitation training combined with 100 cases.The serum levels of inflammatory cytokines and serum pulmonary fibrosis indexes were compared between the two groups before treatment,6 months after treatment and 1 years later.Results There was no significant difference in serum MCP-1,IL-6,IL-8,IL-12,IL-17,IL-18 content in the two groups before treatment,and there was no statistical significance(P>0.05).The serum levels of MCP-1,IL-6,IL-8,IL-12,IL-17 and decreased in the serum of the two groups after the treatment and 1 years after treatment were significantly decreased,but the patients in the observation group were more than the control group.The difference was statistically significant(P<0.05).There was no significant difference in serum HO-1,ICAM-1,HA,LN and PC III content before treatment in the two groups,and there was no statistical significance(P>0.05).The serum levels of HO-1,ICAM-1,HA,LN and PC III in the serum of two groups after the treatment and 1 years after treatment were significantly decreased,but the patients in the observation group were lower than the control group,and the difference was statistically significant(P<0.05).Conclusion The effect of respiratory rehabilitation training combined with Bailing Capsule in the treatment of silicosis with COPD is significant.It can effectively reduce the inflammatory response and inhibit pulmonary fibrosis.It is worthy of clinical promotion.

关 键 词：呼吸康复训练 百令胶囊 矽肺 COPD 炎性反应 肺纤维化 

分 类 号：R563.8[医药卫生—呼吸系统]