昆虫杆状病毒基因组学研究进展  

Advances in Genomics Research of Insect Baculovirus

作　　者：梁振普[1] 刘雅静[1] 张小霞[1] 李鹏娟[1] 王亮 张俊庆[1] LIANG Zhenpu;LIU Yajing;ZHANG Xiaoxia;LI Pengjuan;WANG Liang;ZHANG Junqing(College of Life Sciences,Henan Agricultural University,Zhengzhou 450002,China)

机构地区：[1]河南农业大学生命科学学院,河南郑州450002

出　　处：《河南农业科学》2018年第9期1-7,共7页Journal of Henan Agricultural Sciences

基　　金：国家自然科学基金项目(31570151;31272094);河南省高校科技创新人才支持计划项目(17HASTIT039);河南省高等学校重点科研项目(15A210039)

摘　　要：杆状病毒(Baculoviruses)是一类在自然界中专一性感染节肢动物的共价闭合双链环状DNA病原微生物。由于杆状病毒的宿主特异性高,其作为无公害生物杀虫剂在生物防治方面发挥重大作用。此外,杆状病毒已被开发成为高效的真核表达载体,广泛应用于药物研发、疫苗生产等领域,并作为基因治疗载体用于疾病的基因治疗。综述了获得全基因组序列的昆虫杆状病毒类别及其序列特征,以及昆虫杆状病毒基因组中的主要功能基因,包括RNA转录相关基因、DNA复制相关基因、结构蛋白基因等,也对其应用做了较为详尽的阐述。Baculovirus is a kind of covalently closed double stranded circular DNA insect virus.Because of the host specificity of baculovirus,it plays a major role in biological control as a pollution-free biological insecticide.In addition,baculovirus has been developed as an efficient eukaryotic expression vector and is widely used in drug development,vaccine production and so on,meanwhile used in gene therapy of disease as a gene therapy vector.This paper reviews recent research progress on the genomics of insect baculovirus,including its sequence characteristics and main functional genes such as transcription related genes,DNA replication related genes,and structure related genes,and also gives a detailed description of its application.

关 键 词：昆虫杆状病毒 基因组学 功能基因 应用 

分 类 号：S476.13[农业科学—农业昆虫与害虫防治]