血浆D-二聚体检测对急性缺血性脑卒中的临床意义  

Clinical Significance of Plasma D-dimer Detection in Acute Ischemic Stroke

作　　者：徐高飞[1] XU Gao-fei(Department of Neurology,Jiangdu People's Hospital,Yangzhou,Jiangsu Province,225200 China)

机构地区：[1]扬州市江都人民医院神经内科,江苏扬州225200

出　　处：《中外医疗》2018年第23期78-80,共3页China & Foreign Medical Treatment

摘　　要：目的探究在急性脑卒中的临床诊断中血浆D-二聚体检测的临床意义。方法方便选取2016年3月—2018年3月期间收入该院接受治疗的急性脑卒中患者40例作为观察组,另取同期进行治疗的非急性缺血性的脑卒中患者40例作为对照组,对比两组患者的血浆D-二聚体水平,并通过神经功能缺损评分对脑卒中患者进行分组后对比不同组别患者的血浆D-二聚体水平。结果与后循环缺血的对照组患者相比,急性缺血性脑卒中观察组患者的D-二聚体水平为(1.98±0.09)mg/L,显著较高[对照组为(0.81±0.05)mg/L](t=5.446,P<0.05);对于急性缺血性脑卒中患者的不同分型患者来讲,重型患者的D-二聚体水平高于中型与轻型患者,随患者严重程度D-二聚体水平升高;急性缺血性脑卒中患者中,腔隙性脑卒中患者的D-二聚体水平为(1.95±0.09)mg/L,显著高于非腔隙性脑卒中患者[(1.54±0.09)mg/L](t=3.738,P<0.05)。结论相比非急性脑卒中患者,急性脑卒中患者的血浆D-二聚体水平会发生显著升高,并且在急性脑卒中患者不同分型中,患者神经功能缺损评分越高,血浆D-二聚体水平越高,可根据D-二聚体水平来指示患者脑卒中程度,值得临床参考。Objective To explore the clinical significance of plasma D-dimer detection in the clinical diagnosis of acute stroke.Methods 40 patients with acute stroke who received treatment in the hospital from March 2016 to March 2018 were conveniently selected as the observation group,and 40 patients with non-acute ischemic stroke who were treated during the same period as the control group were compared.Plasma D-dimer levels in both groups were compared and the plasma D-dimer levels were compared in groups of patients after stratification by neurological deficit scores.Results The D-dimer level in the observation group of patients with acute ischemic stroke was(1.98±0.09)mg/L,which was significantly higher than that of the control group with posterior circulation ischemia[control group(0.81±0.05)mg/L](t=5.446,P<0.05);D-dimer levels in severe patients were higher than those in medium-sized and mild patients and were severe in patients with different types of ischemic stroke patients.The level of D-dimer increased;in patients with acute ischemic stroke,the D-dimer level in patients with lacunar stroke was(1.95±0.09)mg/L,which was significantly higher than that of non-lacunar brain stroke patients(1.54±0.09)mg/L(t=3.738,P<0.05).Conclusion Compared with patients with non-acute stroke,plasma D-dimer levels in patients with acute stroke are significantly higher,and in different types of patients with acute stroke,the higher the neurological deficit score the plasma D-II,the higher the level of polymer,the degree of stroke can be indicated according to the level of D-dimer,which is worthy of clinical reference.

关 键 词：血浆D-二聚体 急性脑卒中 临床意义 

分 类 号：R446[医药卫生—诊断学]