miRNAs调控动脉粥样硬化相关细胞功能研究进展  

Research Progresses of miRNAs in Regulation of Cellular Functions in Atherosclerosis

作　　者：陈笑梅 牟雅琳 吕鹏 刘刚[1] CHEN Xiaomei;MU Yalin;Lü Peng;LIU Gang(Center for Molecular Imaging and Translational Medicine,School of Public Health,Xiamen University,Xiamen 361102,China)

机构地区：[1]厦门大学公共卫生学院,分子影像暨转化医学研究中心,福建厦门361102

出　　处：《厦门大学学报（自然科学版）》2018年第5期593-601,共9页Journal of Xiamen University：Natural Science

基　　金：国家重点研发计划(2017YFA0205201,2014CB744503,2013CB733802);国家自然科学基金(81422023,51273165,U1705281,U1505221);教育部新世纪优秀人才支持计划(ncet-13-0502)

摘　　要：动脉粥样硬化及其所引起的恶性心血管疾病,如心肌梗死、中风,是当前致死和致伤残的主要原因.miRNAs是生物进化过程中的一组高度保守的非编码单链RNA小分子,是动脉粥样硬化病理生理细胞效应的主要调节者.主要综述了miRNAs在动脉粥样硬化发展进程中,对内皮细胞、血管平滑肌细胞和巨噬细胞功能的调节作用.Atherosclerosis and its accompanying clinical disease,such as stroke,myocardial infarction,are the leading cause of mortality and morbidity in the world.Over the past decade,miRNAs have emerged as evolutionarily conserved non-coding single-strand RNA molecules and serve as important regulators of pathophysiological cellular effects involved in atherosclerosis.This review aims to provide a comprehensive perspective of miRNAs,mostly focusing on mechanism and relevance in regulating endothelial cell,vascular smooth muscle cell and macrophage functions in the pathogenesis of atherosclerosis.

关 键 词：MIRNA 动脉粥样硬化 内皮细胞 血管平滑肌细胞 巨噬细胞 

分 类 号：R543[医药卫生—心血管疾病]