CO_2点阵激光联合他克莫司治疗局限型白癜风的临床疗效  

Clinical efficacy of fractional carbondioxide laser combined with tacrolimus ointment in treatment of localized vitiligo

作　　者：孙铭徽[1] 陈香儒 刘翔宇[2] 贾玉玺[1] 姜日花[1] SUN Minghui;CHEN Xiangru;LIU Xiangyu;JIA Yuxi;JIANG Rihua(Department of Dermatology,China-Japan Union Hospital,Jilin University,Changchun 130033,China;Department of Plastic Surgery,Second Affiliated Hospital,Peking University,Beijing 100191,China)

机构地区：[1]吉林大学中日联谊医院皮肤科,吉林长春130033 [2]北京大学第二附属医院整形外科,北京100191

出　　处：《吉林大学学报（医学版）》2018年第5期1061-1064,共4页Journal of Jilin University：Medicine Edition

基　　金：吉林省科技厅国际合作处基金资助课题(20150414033GH)

摘　　要：目的:比较CO_2点阵激光联合他克莫司软膏与单纯他克莫司软膏外用治疗局限型白癜风的疗效及不良反应,并评价其安全性。方法:回顾性分析98例局限型白癜风患者临床资料,依患者治疗意愿分为CO_2点阵激光联合他克莫司软膏组(观察组)51例和他克莫司软膏外用组(对照组)47例。对照组患者皮损每天早晚外用他克莫司软膏,观察组患者每天早晚外用他克莫司软膏的同时行CO_2点阵激光治疗,每4周1次,治疗12周,2组患者均按病情联用复方甘草酸苷片(每次3片,每日3次口服,共12周),治疗期间每2周随访1次,治疗结束后12周评价疗效。结果:观察组患者治疗起效时间少于对照组(t=13.82,P=0.001),观察组患者治疗总有效率高于对照组(χ~2=4.72,P<0.05),观察组和对照组患者面颈部皮损治疗有效率高于躯干部(χ~2=23.78,P<0.05;χ~2=12.79,P<0.05),观察组患者面颈部皮损治疗有效率高于对照组(χ~2=5.75,P<0.05)。所有患者在治疗过程中均未出现严重不良反应。结论:CO_2点阵激光联合他克莫司软膏治疗局限型白癜风具有见效快、疗效好和安全性高的优势,值得临床上推广应用。Objective:To compare the curative effects and adverse reactions of fractional carbondioxide laser combined with tacrolimus ointment and tacrolimus ointment alone in the treatment of localized vitiligo,and to evaluate their safeties.Methods:The clinical materials of 98 patients with localized vitiligo were retrospectively analyzed.The patients were divided into two groups according to their wishes.The patients in control group(47 cases)were treated with tacrolimus ointment every morning and evening only,and the patients in observation group(51 cases)were treated with fractional carbondioxide laser combined with tacrolimus ointment and the laser was used once every 4 weeks.The treatment lasted for 12 weeks.Compound Glycyrrhizin Tablets were used according to the conditions(3 pieces each time,3 times a day,a total of 12 weeks).The follow-up period was once every 2 weeks.The clinical efficacy and adverse reactions of the patients in two groups were assessed in the 12th weeks after treatment.Results:The onset time of treatment of the patients in observation group was shorter than that in control group(t=13.82,P=0.001),and the total effective rate of the patients in observation group was higher than that in control group(χ2=4.72,P<0.05).The effective rates of the faciocervical lesion of the patients in observation group and control group were higher than those of the trunk lesion(χ2=23.78,P<0.05;χ2=12.79,P<0.05).The effective rate of the faciocervical lesion of the patients in observation group was higher than that in control group(χ2=5.75,P<0.05);there were no serious adverse reactions in all patients.Conclusion:The combination of fractional carbondioxide laser and tacrolimus ointment in the treatment of localized vitiligo has the advantages of quick effect,good efficacy and high safety,and is worthy of clinical application.

关 键 词：白癜风 二氧化碳点阵激光 他克莫司 点阵激光 

分 类 号：R751.05[医药卫生—皮肤病学与性病学]