两亲性光敏剂五聚赖氨酸酞菁锌的抗菌机理  

Antimicrobial mechanism of amphiphilic photosensitizer pentalysine β-Carbonylphthalocyanine zinc against bacteria

作　　者：刘大锋 袁彩 陈静怡 陈卓[2] 黄明东[2,3] LIU Dafeng;YUAN Cai;CHEN Jingyi;CHEN Zhuo;HUNAG Mingdong(School of Life Sciences,Fujian Agriculture and Forestry University;State Key Laboratory of Structural Chemistry,Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences;College of Chemistry,Fuzhou University,Fuzhou,Fujian 350002,China)

机构地区：[1]福建农林大学生命科学学院 [2]中国科学院福建物质结构研究所,结构化学国家重点实验室 [3]福州大学化学学院,福建福州350002

出　　处：《福建农林大学学报（自然科学版）》2018年第5期626-632,共7页Journal of Fujian Agriculture and Forestry University:Natural Science Edition

基　　金：国家自然科学基金(31670739,L1405229,31570745).

摘　　要：测定了光敏剂五聚赖氨酸酞菁锌分别被大肠杆菌(ATCC25922)和金黄色葡萄球菌(ATCC6538)吸附的量对其表面电荷和细胞壁的影响,以及与两种消毒剂(聚六亚甲基双胍盐酸盐和过氧化氢)的联合抑菌作用,试验结果表明,随着光敏剂浓度的增加,菌体表面的电荷数增大、菌体壁的损伤程度增加.We measured the amount of PS-pentalysineβ-Carbonylphthalocyanine zinc bound to Escherichia coli(ATCC25922)and Staphylococcus aureus(ATCC6538),the zeta potential of bacterial surface in the presence of PS,the damage of bacterial cell wall,the joint antimicrobial effects of the PS together with polyhexamethylene biguanidine hydrochloride(PHMB)or hydrogen peroxide(H2O2).The results show-ed that the charges of bacterial surface and the damage of bacterial cell wall increased with PS concentration.

关 键 词：五聚赖氨酸酞菁锌(光汰净) 最低抑菌浓度 细胞吸附 电动电位 部分抑菌浓度 

分 类 号：Q936[生物学—微生物学]