pH药物控释的氮掺杂碳点载运阿霉素用于光热与化疗的协同治疗（英文）  

pH-Controlled Drug Release of Nitrogen Doped Carbon Dots Delivering Doxorubicine for Synergetic Photo-Thermal Therapy and Chemotherapy

作　　者：杨正 谢安建[1] 沈玉华[1] YANG Zheng;XIE An-Jian;SHEN Yu-Hua(School of Chemistry and Chemical Engineering,Collaborative Innovation Center of Modern Bio-Manufacture,Anhui University,Hefei 230601,China)

机构地区：[1]安徽大学化学与化工学院,现代生物制造协同创新中心,合肥230601

出　　处：《无机化学学报》2018年第10期1775-1782,共8页Chinese Journal of Inorganic Chemistry

基　　金：国家自然科学基金(No.21571002和No.21671001)和安徽省环境友好高分子材料重点实验室项目。

摘　　要：提出一种利用氮掺杂碳点(N-CDs)的光热性能与化疗药物阿霉素(Dox)相结合的联合治疗肿瘤模式。实验结果标明,所制备的N-CDs的分散液经光照后升温可达10℃,是性能优异的光热剂。同时,载运Dox后的N-CDs-Dox纳米复合物还具有pH触发的药物控释作用。因此,这种多功能的N-CDs-Dox纳米复合物能够实现光热和化疗的协同作用,有效杀伤肿瘤细胞。A brand new treatment was reported to cure the cancer triumphantly using the combination of photo-thermal therapy inducing by nitrogen doped carbon dots(N-CDs)and chemotherapy of the doxorubicin(Dox).The experiment results demonstrated that the as-synthesized N-CDs had excellent photo-thermal effect inducing the temperature enhancement as high as about 10℃.Furthermore,the as-prepared N-CDs could load Dox availably and achieve a pH-controlled drug release.Thus,the multifunctional N-CDs-Dox nanocomposites could perform the synergetic effect of photo-thermal therapy and chemotherapy to tumor cells.

关 键 词：pH药物控释 抗肿瘤剂 氮掺杂碳点 药物载运 水热合成 光热治疗 化疗 协同作用 

分 类 号：O611.4[理学—无机化学] TB333[理学—化学]