不明原因复发性流产孕妇检测狼疮抗凝物质和同型半胱氨酸的意义  

Clinical significance of screening lupus anticoagulant and homocysteine in unknown recurrent spontaneous abortion women

作　　者：何全利[1] 刘伟[1] 杨思伟[1] 任冬梅[1] Quan-li He;Wei Liu;Si-wei Yang;Dong-mei Ren(Department of Clinical Laboratory,the People’s Hospital of Jiaozuo City,Jiaozuo,Henan 454002,China)

机构地区：[1]河南省焦作市人民医院检验科,河南焦作454002

出　　处：《中国现代医学杂志》2018年第27期94-97,共4页China Journal of Modern Medicine

摘　　要：目的分析探讨狼疮抗凝物质(LA)、同型半胱氨酸(Hcy)及抗心磷脂抗体(ACA)在临床不明原因复发性流产(URSA)孕妇中的应用价值。方法选取89例URSA患者作为观察组和60例非孕期正常妇女为对照组。取外周血进行血浆LA和血清Hcy、ACA及叶酸(FA)水平检测统计分析。结果与对照组相比较,观察组LA、Hcy及ACA水平增高(P <0.05),而FA水平降低(P <0.05);观察组LA水平与Hcy水平呈正相关(r=0.586,P=0.008)。结论通过检测LA、HCY等指标,对早期发现具有URSA风险的患者并进行预防性治疗。Objective To investigate the application of screening lupus anticoagulant(LA),homocysteine(Hcy)and folic acid(FA)in recurrent spontaneous abortion pregnant women with unknown causes.Methods A total of 89 recurrent spontaneous abortion patients with unknown causes were enrolled in the URSA group,while another 60 non-pregnant healthy women were selected in the control group.Plasma levels of LA,Hcy,ACA and FA were measured.Results peripheral concentration of LA,Hcy and ACA increased while FA decreased significantly in URSA group when compared with control group(P<0.05).Concentration of LA was positively correlated with Hcy in URSA(P<0.05).Conclusion LA,Hcy and ACA may be promising diagnostic biomarkers for early discovery of URSA.

关 键 词：狼疮抗凝物质 同型半胱氨酸 复发性流产 

分 类 号：R446.1[医药卫生—诊断学]