甲状腺功能亢进型心脏病患者血清甲状腺过氧化物酶抗体、甲状腺球蛋白抗体水平的变化及意义  

Changes of serum thyroid peroxidase antibody and thyroglobulin antibody in patients with hyperthyroidism heart disease

作　　者：王瑶 WANG Yao(Department of Ultrasound,Sanya People's Hospital,Sanya 572000,Hainan,China)

机构地区：[1]三亚市人民医院超声科,海南三亚572000

出　　处：《检验医学》2018年第9期790-793,共4页Laboratory Medicine

摘　　要：目的探讨甲状腺功能亢进型心脏病(HHD)患者血清甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TgAb)水平的变化及意义。方法选取HHD患者100例、单纯甲状腺功能亢进症(简称甲亢)患者100例,收集所有患者的一般资料[性别、年龄、体重指数(BMI)、甲亢病程、平均动脉压(MAP)],同时检测其血清TPOAb、TgAb水平。结果 HHD组性别、年龄、BMI、甲亢病程、MAP与甲亢组比较,差异均无统计学意义(P>0.05)。HHD组治疗前后血清TPOAb、TgAb水平均明显高于甲亢组(P<0.001),HHD组治疗后血清TPOAb、TgAb水平均明显低于治疗前(P<0.001)。HHD组治疗有效76例(76.00%)、治疗无效24例(24.00%)。HHD治疗有效者治疗后血清TPOAb、TgAb水平均明显低于治疗前及治疗无效者(P<0.001),HHD治疗无效者治疗前后血清TPOAb、TgAb水平差异均无统计学意义(P>0.05)。HHD治疗有效者治疗后血清TPOAb、TgAb水平与甲亢组比较,差异均无统计学意义(P>0.05)。结论血清TPOAb、TgAb水平可能与HHD的发生及转归有关,可作为评估HHD患者疗效的参考指标。Objective To investigate the changes of serum thyroid peroxidase antibody(TPOAb)and thyroglobulin antibody(TgAb)in patients with hyperthyroidism heart disease(HHD).Methods A total of 100 patients with HHD and 100 patients with hyperthyroidism were enrolled,and their general data[sex,age,body mass index(BMI),hyperthyroidism course and mean arterial pressure(MAP)]were collected.Serum TPOAb and TgAb levels were determined.Results There was no statistical significance for sex,age,BMI,hyperthyroidism course and MAP between HHD and hyperthyroidism groups(P>0.05).Serum TPOAb and TgAb levels in HHD group were higher than those in hyperthyroidism group before and after treatment(P<0.001).In HHD group,serum TPOAb and TgAb after treatment were lower than those before treatment(P<0.001).There were 76 effective cases(76.00%)and 24 invalid cases(24.00%)in HHD group.After treatment,serum TPOAb and TgAb levels in effective cases were lower than those before treatment and in invalid cases(P<0.001).For invalid cases,serum TPOAb and TgAb levels had no statistical significance before and after treatment(P>0.05).Serum TPOAb and TgAb levels in effective cases after treatment had no statistical significance compared with hyperthyroidism group(P>0.05).Conclusions Serum TPOAb and TgAb levels may be related to the occurrence and transfer of HHD,and they can be used as reference indices for evaluating curative effects.

关 键 词：甲状腺过氧化物酶抗体 甲状腺球蛋白抗体 甲状腺功能亢进型心脏病 

分 类 号：R446.1[医药卫生—诊断学]