307例吸毒者尿蛋白检测结果分析  

Analysis of the results of urinary protein determination in 307 cases with drug addicts

作　　者：王薇 王蕾[1] 周芳芳 关晶 李永烶 许浩东[1] WANG Wei;WANG Lei;ZHOU Fangfang;GUAN Jing;LI Yongting;XU Haodong(Department of Clinical Laboratory,Shanghai Eighth People's Hospital,Shanghai 200030,China;Department of Clinical Laboratory,Yuncheng Central Hospital,Yuncheng 044000,Shanxi,China)

机构地区：[1]上海市第八人民医院检验科,上海200030 [2]运城市中心医院检验科,山西运城044000

出　　处：《检验医学》2018年第9期827-829,共3页Laboratory Medicine

摘　　要：目的通过检测吸毒者尿液总蛋白(TP)、微量白蛋白(mAlb)、α1-微球蛋白(α1-MG)水平,评估吸毒者的肾功能状况。方法检测307例吸毒者和201名体检健康者(正常对照组)尿液TP、mAlb、α1-MG水平。根据吸毒者吸食毒品的种类分为冰毒组(213例)、吗啡组(30例)、混吸组(36例)和其他组(28例),比较各组各项目的检测结果。结果吸毒组尿TP、mAlb、α1-MG水平均明显高于正常对照组(P<0.000 1)。冰毒组mAlb水平高于吗啡组(P<0.05),而尿TP和α1-MG水平低于吗啡组(P<0.05)。吗啡组尿mAlb水平低于混吸组(P<0.05)。混吸组尿α1-MG水平高于其他组(P<0.05)。男性吸毒者尿TP及α1-MG水平明显高于女性(P<0.05、P<0.001),而mAlb差异无统计学意义(P>0.05)。结论冰毒对肾小球的损伤更为严重,吗啡对肾小管的损伤更为严重。应高度重视并加强对吸毒者的健康干预,有效地控制毒品危害。Objective To assess the status of renal function of cases with drug addicts by determining urinary total protein(TP),microalbumin(mAlb)and alpha 1-microglobulin(α1-MG)levels.Methods Urinary TP,mAlb andα1-MG levels were determined in 307 cases with drug addicts and 201 healthy subjects(healthy control group).According to the types of drugs taken by the cases with drug addicts,they were classified into methamphetamine group(213 cases),morphine group(30 cases),mixed group(36 cases)and the other group(28 cases).Their results were compared.Results The TP,mAlb andα1-MG levels in drug addict group were higher than those in healthy control group(P<0.000 1).The mAlb level in methamphetamine group was higher than that in morphine group(P<0.05),but the TP andα1-MG levels were lower(P<0.05).The mAlb level in morphine group was lower than that in mixed group(P<0.05).Theα1-MG level in mixed group was higher than that in the other group(P<0.05).The urinary TP andα1-MG levels of male drug addicts were higher than those of female drug addicts(P<0.05,P<0.001),and mAlb had no statistical significance(P>0.05).Conclusions Methamphetamine tends to cause serious damage to glomerulus,while morphine tends to cause serious damage to renal tubule.It should pay attention to strength the health intervention for drug addicts and control the harm of drugs.

关 键 词：总蛋白 微量白蛋白 Α1-微球蛋白 肾功能 吸毒者 

分 类 号：R446.1[医药卫生—诊断学]