4种麻醉药物对家兔手术的麻醉效果比较  

Comparison of anesthetic effect of Urethane, Sodium pentobarbital, Propofol and Sodium thiopental in rabbits

作　　者：孟永亮 孙彦 Yong-liang Meng;Yan Sun(Qilu Medical College,Zibo,Shandong 255213,China)

机构地区：[1]齐鲁医药学院,山东淄博255213

出　　处：《中国现代医学杂志》2018年第23期12-15,共4页China Journal of Modern Medicine

基　　金：山东省医学教育研究中心第六批教育科研规划课题(No:YJKT201344)

摘　　要：目的比较乌拉坦、戊巴比妥钠、异丙酚、硫喷妥钠4种麻醉药物对实验家兔外科手术的麻醉效果。方法将12只健康的实验家兔分为4组,每组3只,分别经耳缘静脉缓慢推注乌拉坦(20.0%,4 ml/kg)、戊巴比妥钠(0.7%,1 ml/kg)、异丙酚(1.0%,1 ml/kg)、硫喷妥钠(2.5%,0.6 ml/kg)。记录各组呼吸频率、心率、麻醉起效时间、麻醉维持时间、麻醉苏醒时间,并进行比较。结果乌拉坦组、戊巴比妥钠组、异丙酚组、硫喷妥钠组的麻醉起效时间分别为(6.4±0.8)、(9.0±0.6)、(7.7±0.3)和(3.1±0.5)min,麻醉维持时间分别为(32.2±3.7)、(40.1±6.5)、(43.4±3.9)和(30.6±3.7)min,术后苏醒时间依次为(25.2±3.7)、(13.6±6.4)、(12.1±3.9)、(5.1±1.4)min。结论采用2.5%硫喷妥钠对实验家兔进行麻醉起效最快;1.0%异丙酚麻醉时间最长,适用于较长时间观察的动物实验;20.0%乌拉坦麻醉维持时间长,术后死亡率高,适用于实验要求不高,术后要处死动物的实验。Objective To compare the anesthetic effect of Urethane(ethyl carbamate),Sodium pentobarbital,Propofol and Sodium thiopental in rabbit surgery as appendectomy.Methods Twelve healthy rabbits were divided into 4 groups,with 3 in each group,the anesthesia drugs were slowly injected through their auricular veins.The rabbits in the group A were given Urethane(20.0%,4 ml/kg),the rabbits in the group B received Sodium pentobarbital(0.7%,1 ml/kg),the rabbits in the group C were given Propofol(1.0%,1 ml/kg),and those in the group D received Sodium thiopental(2.5%,0.6 ml/kg).The respiratory rate,heart rate,anesthetic onset time,duration of anesthesia,and anesthetic recovery time were recorded and compared among the 4 groups.Results In the groups A,B,C and D,the onset time was(6.4±0.8),(9.0±0.6),(7.7±0.3)and(3.1±0.5)min respectively;the duration of anesthesia was(32.2±3.7),(40.1±6.5),(43.4±3.9)and(30.6±3.7)min respectively;the postoperative recovery time was(25.2±3.7),(13.6±6.4),(12.1±3.9)and(5.1±1.4)min.Conclusions For surgical anesthesia of experimental rabbits,2.5%Sodium thiopental has the fastest onset;1.0%Propofol has the longest anesthetic time,is suitable for animal experiments requiring long-term observation;20.0%Urethane has a long anesthesia maintenence time and high postoperative mortality,and is suitable for the experiments without high experimental requirements and the animals should be sacrificed after operation.

关 键 词：麻醉 乌拉坦 戊巴比妥钠 异丙酚 硫喷妥钠 

分 类 号：R614[医药卫生—麻醉学]