慢性丙型肝炎病毒患者APRI评分与肝功能、凝血功能的相关性  

Correlations of aspartate aminotransferase-to-platelet ratio index with liver function and coagulation function in chronic hepatitis C patients

作　　者：刘文俊[1] 杨霞芳[1] 覃前 陆小旭 Wen-jun Liu;Xia-fang Yang;Qian Qin;Xiao-xu Lu(The People’s Hospital of Guangxi Zhuang Autonmous Region,Nanning,Guangxi Zhuang Autonmous Region 530021,China)

机构地区：[1]广西壮族自治区人民医院,广西南宁530021

出　　处：《中国现代医学杂志》2018年第23期61-64,共4页China Journal of Modern Medicine

基　　金：广西壮族自治区卫生和计划生育委员会自筹经费项目(No:Z2016629)

摘　　要：目的探讨不同程度肝损伤慢性丙型肝炎病毒(HCV)患者天门冬氨酸氨基转移酶与血小板比值(APRI)评分、肝功能及凝血功能之间的关系。方法检测受试者的肝功能、血小板及凝血功能指标,计算APRI评分,对相关指标进行比较分析。结果 HCV组患者血浆纤维蛋白原(FIB)、APRI评分、总胆红素(TBIL)、γ-谷氨酰转肽酶(γ-GT)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)及D二聚体(D-D)水平与健康体检组比较有差异(P<0.05)。患者TBIL、γ-GT、APTT、PT及TT与APRI评分呈正相关(P<0.05),FIB与APRI评分呈负相关(P<0.05)。结论慢性HCV患者肝功能、凝血功能与APRI评分相关,对评估慢性HCV患者肝损伤趋势有重要意义。Objective To approach the correlation between liver function,blood coagulation function and aspartate aminotransferase-to-platelet ratio index(APRI)in chronic hepatitis C patients with different degrees of liver injury.Methods Liver function,platelet and blood coagulation function were detected by automation instruments,and then APRI was calculated.The related indexes were analyzed and compared.Results The levels of plasma fibrinogen(FIB),APRI,total bilirubin(TBIL),gamma-glutamyl transpeptidase(γ-GT)and D-dimer,and activated partial thromboplastin time(APTT),prothrombin time(PT)and thrombin time(TT)were significantly different between the patients and the healthy controls(P<0.05).The result of correlation analysis showed that TBIL,γ-GT,APTT,PT and TT were positively correlated with APRI(P<0.05),while FIB had a negative correlation with APRI(P<0.05).Conclusions Liver function and coagulation function have correlations with APRI in chronic hepatitis C patients,and all of the indexes have important clinical significance in evaluation of the extent of liver injury in the patients.

关 键 词：丙型肝炎 肝功能 凝血功能 天门冬氨酸氨基转移酶与血小板比值 肝损伤 

分 类 号：R446.1[医药卫生—诊断学]