TCF7L2基因rs7903146遗传变异与妊娠期糖尿病发病的系统评价  

Systematic evaluation on relationship between TCF7L2 gene rs7903146 genetic variation and gestational diabetes mellitus

作　　者：李友珍 陆慧群 韦丽娜 陆德飘 覃珍华 徐震 刘桂熊 韦柏州 郑惠婷 罗秀云 韦琴 梁伟燕 秦胜花[3] 于祥远 LI Youzhen;LU Huiqun;WEI Lina;LU Depiao;QIN Zhenhua;XU Zhen;LIU Guixiong;WEI Bozhou;ZHENG Huiting;LUO Xiuyun;WEI Qin;LIANG Weiyan;QING Shenghua;YU Xiangyuan(Teaching and Researching Section of Epidemiology and Health Statistics,Guilin,Guangxi 541100,China;Specialty of Health Inspection,Guilin,Guangxi 541100,China;Specialty of Preventive Medicine,School of Public Health,Guilin Medical University,Guilin,Guangxi 541100,China;Physical Examination Center,First Affiliated Hospital,Guilin Medical College,Guilin,Guangxi 541001,China)

机构地区：[1]桂林医学院公共卫生学院流行病与卫生统计学教研室,广西桂林541100 [2]桂林医学院公共卫生学院,广西桂林541100 [3]桂林医学院第一附属医院体检中心,广西桂林541001

出　　处：《重庆医学》2018年第27期3552-3556,3564,共6页Chongqing medicine

基　　金：广西教育厅高校科研项目(KY2015YB223);广西自然科学基金(2016GXNSFAA380274);自治区级大学生创新创业训练计划项目(201710601103);桂林市科技开发计划项目(20150206-1-11)

摘　　要：目的系统评价转录因子7类似物-2(TCF7L2)rs7903146C>T与妊娠期糖尿病(GDM)发病的关系。方法截止2017年8月31日,检索Medline、中国生物医学文献检索数据库(CBM disc)、万方数据知识服务平台及中国知网(CNKI)等国内外期刊数据库关于rs7903146多态性与GDM发病相关的病例-对照研究。计算OR及相应95%CI,估计该遗传变异与GDM发病风险的关系。结果共纳入17篇文献,包括13 950例研究对象(GDM组5 066例,对照组8 884例)。Meta分析结果显示,显性遗传模型下,rs7903146C>T与GDM易感性显著关联,与TT基因型相比,C等位基因携带者GDM发病风险明显降低,OR(95%CI)=0.67(0.54~0.84);隐性模型下,与T等位基因携带相比,CC基因型可显著降低GDM的发病风险,OR(95%CI)=0.64(0.56~0.74)。结论 TCF7L2rs7903146C>T影响妊娠期妇女对GDM的易感性,C等位基因可能是预防GDM发生的保护性遗传因素。Objective To systematically evaluate the relationship between the transcription factor 7 like-2(TCF7L2)gene rs7903146 C>T and the onset of gestational diabetes(GDM).Methods The case-control studies of rs7903146 polymorphosm and GDM onset were retrieved from Medline,CBMdisc,Wanfang Data knowledge service platform and Chinese national knowledge internet(CNKI)until August 31,2017.The pooled OR and the corresponding 95%confidence interval were calculated to assess the relationship between its genetic variation with GDM onset risk.Results A total of 17 literatures were included,including 13 950 study subjects(5 066 cases in the GDM group and 8 884 cases in the control subjects).The meta analysis results showed that rs7903146 C>T was significantly associated with the onset of GDM under the dominant model,compared with the TT genotype,the GDM onset risk in C allele carriers was significantly decreased[OR 95%=CI 0.67(0.54-0.84)];and under the recessive model,compared with the T allele genotypes,CC gynotype could significantly reduce the onset risk of GDM[OR and 95%CI 0.64(0.56-0.74)].Conclusion TCF7L2 rs7903146 C>T affects the susceptibility to GDM in pregnancy women,and C allele may be a protective hereditary factor in the prevention of the occurrence of GDM.

关 键 词：妊娠并发症 糖尿病 转录因子7类似物-2 发病风险 遗传变异 

分 类 号：R714.25[医药卫生—妇产科学]