自拟益气温阳方对中晚期非小细胞肺癌患者化疗后骨髓抑制的影响  

Effect of Invigorate Qi and Warm Yang Formula on Myelosuppression in Patients with Advanced Non-Small Cell Lung Cancer after Chemotherapy

作　　者：陆程洁 高静东[2] 刘敏[2] 陈婷[2] 陈嘉璐[2] 殷平 LU Cheng-jie;GAO Jing-dong;LIU Min;CHEN Ting;CHEN Jia-lu;YIN Ping(Rehabilitation Department of TCM,The First People's Hospital of Wujiang District,Suzhou,215200,China;Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine,Suzhou,215009,China;Department of Pediatrics,The Fifth People's Hospital of Wujiang District,Suzhou,215200,China)

机构地区：[1]苏州市吴江区第一人民医院中医康复科,江苏苏州215200 [2]南京中医药大学苏州附属医院,江苏苏州215009 [3]苏州市吴江区第五人民医院儿科,江苏苏州215200

出　　处：《南京中医药大学学报》2018年第5期465-469,共5页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：苏州市科技局科技发展计划(sysd2014121)

摘　　要：目的观察益气温阳方减轻化疗致中晚期非小细胞肺癌肺脾气(阳)虚证患者骨髓抑制的疗效。方法选取患有非小细胞肺癌肺脾(气)阳虚证患者共60例作为试验研究对象。随机分为实验组和对照组,每组30例,对照组采取常规化疗,实验组在此基础上增加益气温阳方治疗,至2期化疗结束。对比化疗前1天、化疗后第2天、化疗后第5天2组血常规、肝肾功能,并对比2组患者化疗前后中医症状、生活质量、相关肿瘤指标、免疫功能指标的变化情况。结果治疗期间实验组骨髓严重抑制发生率低于对照组(P<0.01);实验组治疗后生活质量改善效果相比对照组有一定的优势(P<0.01);实验组在改善中医症状、某些肺癌的特异性肿瘤指标相较于对照组存在一定的优势(P<0.05~0.01)。结论益气温阳方联合化疗治疗中晚期非小细胞肺癌能明显减轻骨髓抑制程度,有效改善患者临床症状,提升疾病治疗稳定率,提高生活质量,且引起不良反应程度较小。OBJECTIVE To observe the efficacy of invigorate qi and warm yang formula on myelosuppression in patients with advanced non small cell lung cancer.METHODS 60 patients with lung and spleen(qi)yang deficiency syndrome of non small cell lung cancer were randomly divided into experimental group and control group,30 cases in each group.The control group was treated with conventional chemotherapy,and the experimental group was treated with invigorating qi and warming yang formula on the basis of control group,until the end of second stage chemotherapy.The blood routine,liver and kidney function were compared between two groups on first day before chemotherapy,the second day and the fifth day after chemotherapy.The changes of TCM symptoms,quality of life,related tumor indicators and immune function indexes were compared before and after chemotherapy.RESULTS The incidence of severe inhibition of bone marrow in experimental group was lower than that in control group during the treatment period(P<0.05).The improvement of quality of life of experimental group was superior to the control group(P<0.05).The experimental group has certain advantages in improving the symptoms of TCM and specific tumors of certain lung cancers compared with the control group(P<0.05).CONCLUSION Invigorating qi and warming yang formula combined with chemotherapy in the treatment of advanced non small cell lung cancer can significantly reduce the degree of myelosuppression and effectively improve the clinical symptoms of patients,the stability of disease treatment,the quality of life,and cause less adverse reactions.

关 键 词：益气温阳方 化疗 骨髓抑制 中晚期非小细胞肺癌 

分 类 号：R273[医药卫生—中西医结合]