绝经后骨质疏松症患者血清ICTP、PINP与血脂相关性的研究  

Study on the correlation among serum ICTP,PINP,and lipid in postmenopausal patients with osteoporosis

作　　者：甘卫冬[1] 眭承志[1] 林振原[1] 樊孝俊[1] 陈舒强[1] 苏春涛[1] 陈祺[1] GAN Weidong;SUI Chengzhi;LIN Zhenyuan;FAN Xiaojun;CHEN Shuqiang;SU Chuntao;CHEN Qi(The First Affiliated Hospital of Xiamen University,Xiamen 361003,China)

机构地区：[1]厦门大学附属第一医院,福建厦门361003

出　　处：《中国骨质疏松杂志》2018年第9期1191-1194,共4页Chinese Journal of Osteoporosis

摘　　要：目的探讨绝经后骨质疏松症患者骨代谢指标(ICTP、PINP)与血脂水平的相关性及可能的机制。方法测定122例绝经后骨质疏松症患者(骨质疏松症组)和122例绝经后健康正常妇女(正常对照组)的血清ICTP、PINP、TG、TC、LDL-C、HDLC等指标,并分析其相关性。结果两组相比较,骨质疏松症组TG、TC、LDL-C高于正常对照组(P<0.05),骨质疏松症组HDL-C低于正常对照组(P<0.05),骨质疏松症组PINP低于正常对照组(P<0.05),骨质疏松症组ICTP高于正常对照组(P<0.05);PINP与TG、TC、LDL-C呈负相关,而与HDL-C呈正相关;ICTP与TG、TC、LDL-C呈正相关,而与HDL-C呈负相关。结论骨质疏松症患者成骨因子PINP水平下降、破骨因子ICTP水平升高与TG、TC、LDL-C升高及HDL-C降低密切相关,高脂血症引起的代谢紊乱与骨质疏松症的发生存在一定的关联性。Objective To explore the relationship between bone metabolism index(ICTP,PINP)and blood lipid level and its possible mechanism in postmenopausal patients with osteoporosis.Methods The levels of ICTP,PINP,TG,TC,LDL-C,and HDL-C in 122 postmenopausal patients with osteoporosis(osteoporosis group)and 122 healthy postmenopausal women(normal control group)were determined.The correlation among the factors was analyzed.Results The levels of TG,TC,and LDL-C in osteoporosis group were higher than those in normal control group(P<0.05).The levels of HDL-C in osteoporosis group were lower than those in normal control group(P<0.05).The levels of PINP in osteoporosis group were lower than those in normal control group(P<0.05).The levels of ICTP in osteoporosis group were higher than those in normal control group(P<0.05).PINP was negatively correlated with TG,TC,and LDL-C,but was positively correlated with HDL-C.ICTP was positively correlated with TG,TC,and LDL-C,but was negatively correlated with HDL-C.Conclusion Decreased osteoblastic factor PINP levels and increased osteoclastic factor ICTP levels in osteoporosis patients are closely associated with elevated TG,TC,LDL-C,and decreased HDL-C levels.The metabolic disorders caused by hyperlipidemia have a certain role in the occurrence of osteoporosis.

关 键 词：骨质疏松症 ICTP PINP 血脂 

分 类 号：R681[医药卫生—骨科学]