磷酸氢二钾催化多组分一锅法反应合成1,4-二氢吡喃并[2,3-c]吡唑衍生物  

Dipotassium Hydrogenphosphate Assisted Multi-component One-Pot Synthesis of 1,4-Hihydropyrano [2,3-c]pyrazole Derivatives

作　　者：李非 毛胜雪 孙越[1] 吕成伟[1] 安悦[1] LI Fei;MAO Shengxue;SUN Yue;Lü Chengwei;AN Yue(School of Chemistry and Chemical Engineering,Liaoning Normal University,Dalian,Liaoning 116029,China)

机构地区：[1]辽宁师范大学化学化工学院,辽宁大连116029

出　　处：《应用化学》2018年第10期1201-1207,共7页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金资助项目(21403100);辽宁省博士启动基金资助项目(20141100);辽宁省教育厅重点实验室项目(L201683656)~~

摘　　要：绿色、简便、高效的催化四组分反应合成吡喃并[2,3-c]吡唑类杂环化合物是当今有机化学领域的研究热点。本文发展了在水与聚乙二醇(PEG-200)的混合液中,廉价易得的磷酸氢二钾(K2HPO4·3H2O)催化乙酰乙酸乙酯、水合肼、芳香醛和丙二腈的多组分"一锅法"反应,合成一系列1,4-二氢吡喃并[2,3-c]吡唑-5-腈衍生物,产率为88%~98%。该方法避免了使用复杂昂贵的催化剂和繁琐的纯化过程。Catalytic one-pot four-component reaction is an ideal strategy for efficient and facile synthesis of pyrano[2,3-c]pyrazoles.The efficacy of dipotassium hydrogenphosphate(K 2 HPO 4·3H 2 O)as a cheap and readily accessible catalyst for the synthesis of 1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile derivatives via one-pot four-component reaction of ethyl acetoacetate,hydrazine hydrate,aryl aldehydes,and malononitrile was described in this paper.These multi-component condensations proceeded smoothly in aqueous polyethylene glycol(PEG-200)and the corresponding products were obtained in 88%~98%yields.This improved protocol eliminates the problems associated with expensive complex catalyst and tedious purification procedures.

关 键 词：磷酸氢二钾 1 4-二氢吡喃并[2 3-c]吡唑-5-腈 多组分 合成 聚乙二醇200水溶液 

分 类 号：O625[理学—有机化学]