季铵盐改性蒙脱石的制备与表征  

Preparation and Characterization of Quaternary Ammonium Modified Montmorillonite

作　　者：彭琪[1] 葛莹莹 李宁林 PENG Qi;GE Ying-ying;LI Ning-lin(College of Chemisty and Chemical Engineering,Xinyang Normal University,Xinyang 464000,China;Department of Pharmacy,Xinyang Central Hospital,Xinyang 464000,China)

机构地区：[1]信阳师范学院化学化工学院,信阳464000 [2]信阳市中心医院药剂科,信阳464000

出　　处：《人工晶体学报》2018年第9期1995-1998,共4页Journal of Synthetic Crystals

基　　金：河南省科技计划项目(162102210403);河南省教育厅自然科学研究项目(12B150026)

摘　　要：采用十六烷基三甲基氯化铵(CTAC)对钠基蒙脱石(MMT)进行季铵化改性,制备有机蒙脱石(CMMT),对改性后的蒙脱石进行X射线衍射(XRD)、电位分析法(PA)、红外光谱(FT-IR)和热分析(TGA)等分析表征,并用改性后的蒙脱石吸附五氟尿嘧啶(5-FU)后测定并比较其载药量。结果表明,改性剂已成功插入到蒙脱石的层间;相比于钠基蒙脱石,有机蒙脱石的层间距和热稳定性均有所增大;当制备季铵盐有机改性蒙脱石时,反应温度为80℃,且CTAC的用量是MMT的2.5倍阳离子交换容量时,形成的有机蒙脱石的阳离子化程度和对5-FU的载药量最高。此外,考察并比较了有机蒙脱石和钠基蒙脱石的体外细胞毒性,结果显示有机蒙脱石具有更好的生物相容性和更低的细胞毒性。Cetyl trimethyl ammonium chloride(CTAC)was used to modify montmorillonite(MMT)to prepare organic montmorillonite(CMMT).The structure of modified montmorillonite was characterized by X-ray diffraction(XRD),potentiometric analysis(PA),infrared spectroscopy(FT-IR)and thermogravimetric analysis(TGA).The drug loading property of the complexes were investigated to absorb the drug of 5-Fluorouracil(5-FU).The results show that CTAC indeed intercalated into the layers of montmorillonite.Compared with MMT,the interlayer spacing and thermal stability of CMMT increased both.The cationic degree and drug loading reached the highest when the amount of CMKGM is equivalent to 2.5 fold of MMT’s cationic exchange capacity under the condition of 80℃.Besides,the in vitro cytotoxicity of CMMT and MMT were investigated,and the results indicate that CMMT has better biocompatibility and lower cytotoxicity.

关 键 词：蒙脱石 季铵化 插层 有机改性 

分 类 号：TB321[一般工业技术—材料科学与工程]