结肠靶向给药系统机理研究进展  

Research advance on mechanism of colon-targeted drug delivery system

作　　者：单安山[1] 杨占一 何诗琪 李家维 SHAN Anshan;YANG Zhanyi;HE Shiqi;LI Jiawei(Institute of Animal Nutrition,Northeast Agricultural University,Harbin 150030,China)

机构地区：[1]东北农业大学动物营养研究所,哈尔滨150030

出　　处：《东北农业大学学报》2018年第9期88-96,共9页Journal of Northeast Agricultural University

基　　金：国家自然科学基金项目(31672434)

摘　　要：肠道微生态紊乱将引发机体一系列疾病,口服结肠靶向给药作为新型药物传递系统,成为治疗局部肠道疾病新途径。文章归纳近年研究进展,详细阐述不同依赖型口服结肠靶向给药系统的给药机理,包括酸碱pH依赖型,时间依赖型,压力控制型,微生物酶触发型,前体药物型及复合型给药系统,为研究者提供参考。Intestinal flora disturbance could cause many serious diseases.Oral colon targeted drug delivery system(OCTDDS),which was a new type of drug delivery system had become a new way for the treatment of local intestinal disease.This review summarized the research progress in this field and introduced relatively contents including pH-dependent,time-dependent,pressure-controlled,microbialtriggered,prodrug-based,and compound drug delivery systems for oral colon targeted drug delivery systems for readers'reference.

关 键 词：口服结肠靶向给药系统 肠道菌群生态 肠道疾病 

分 类 号：R94[医药卫生—药剂学]