早期综合干预对早产低体质量儿血清脂联素、神经发育的影响  

Effect of early comprehensive intervention on serum adiphonectin and neurodevelopment in preterm low birth weight infants

作　　者：许津莉[1] 赵美林 曲海新[1] 郭华贤[1] XU Jinli;ZHAO Meilin;QU Haixin;GUO Huaxian(Department of Neonatology,the First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei 075000,China)

机构地区：[1]河北北方学院附属第一医院新生儿科,075000

出　　处：《重庆医学》2018年第28期3621-3624,共4页Chongqing medicine

基　　金：河北省卫生厅项目(20170788)

摘　　要：目的分析早期综合干预对早产低体质量儿血清脂联素(ADP)、神经发育的影响。方法筛选2015年6月至2017年1月在该院儿科住院的早产/低体质量儿100例,按家长自愿的原则分为干预组50例进行早期综合干预,对照组50例进行常规干预。选择该院同期分娩的正常足月儿30例为健康组,分析3组婴儿在12月龄内的神经发育与ADP情况。结果干预组修订版Bayley婴幼儿发展量表(BSID)评分在3、6、9及12月龄均低于健康组的,高于对照组的,3组组间比较差异有统计学意义(P<0.05);出生第1天,干预组与对照组ADP水平相当,均明显低于健康组(P<0.05);干预组婴儿在12月龄综合干预BSID评分、ADP水平均接近健康组(P>0.05),较对照组明显改善(P<0.05)。3月龄时,3组婴儿组间体质量、身长、头围体格发育比较差异无统计学意义(P>0.05);6、9、12月龄,干预组以上3个指标均优于对照组(P<0.05),逐渐接近健康组(P>0.05)。结论早期综合干预可有效改善早产低体质量儿的神经发育,预防或减轻其伤残的发生,而血清ADP水平可能与其生长发育相关。Objective To analyze the effects of early comprehensive intervention on serum adiphonectin and neurodevelopment in preterm low birth weight infants.Methods According to the parents′wishes,50 patients were divided into intervention group for early comprehensive intervention,and 50 patients into control group for routine interventions.Thirty infants with normal delivery at the same time were selected as the normal group.The neurodevelopment and serum adiphonectin(ADP)of the three groups of infants within 12 months of age were analyzed.Results The BSID scores of the infants in intervention group were lower than those in normal group at 3,6,9 and 12 months of age,and higher than that of control group(P<0.05).On the first day of birth,the ADP level of the intervention group and the control group were significantly lower than those of normal group(P<0.05);but at 12 months of age,the BSID scores and ADP level in intervention group got close to normal group(P>0.05),and better than control group.At 3 months of age,the body weight,body length and head circumference were significantly different between three groups(P<0.05);but the intervention group were superior to control group about the three indicators above at 6,9,12 months of age(P<0.05),and got close to normal group(P>0.05).Conclusion Early comprehensive intervention can effectively improve the neurodevelopment of premature low birth quality children,prevent or reduce the occurrence of disability,and serum ADP levels may be related to the growth.

关 键 词：早期综合干预 早产 婴儿 出生时低体重 脂联素 神经系统 

分 类 号：R473.72[医药卫生—护理学]