急进高原对汽车兵心理应激和神经内分泌免疫功能的影响  

Effects of rapidly entering tibet plateau on psychological stress,neuroendocrine and immune function of automobile soldiers

作　　者：胡光涛[1] 冯正直[2] 王国威[1] 陈许波[1] 黄一[1] 贺旭[1] HU Guangtao;FENG Zhenzhi;WANG Guowei;CHEN Xubo;HUANG Yi;HE Xu(Mental Health Center,324th Hospital of PLA,Chongqing,400041,China;College of Psychology,Third Militay Medical University,Chongqing 400038,China)

机构地区：[1]解放军第324医院精神心理卫生中心,重庆400041 [2]第三军医大学心理学院,重庆400038

出　　处：《重庆医学》2018年第28期3656-3658,3662,共4页Chongqing medicine

基　　金：成都军区"十二五"医学科研重点课题(B12009);军队心理卫生专项科研课题(12XLZ324);军委后勤保障部面上项目(LJ17J019)

摘　　要：目的探讨急进高原对汽车兵心理应激和神经内分泌、免疫功能的影响,为高原汽车兵心理应激防护提供科学依据。方法随机整群抽取由低海拔环境急进高海拔环境执行运输任务的某部汽车兵106名,分别在执行任务前(出发前第3天,营区,海拔600m)、完成任务时(出发后第37天,藏区,海拔4 300m)应用应激反应问卷(SRQ)、状态-特质焦虑问卷(STAI)、特质应对方式问卷(TCSQ)进行心理应激评估,于心理检测后第2天7:00~8:00抽空腹肘静脉血,采用放射免疫方法(RIA)检测血清皮质醇(CORT)、5-羟色胺(5-HT)及白细胞介素-6(IL-6)水平。结果执行任务后汽车兵SRQ总分(47.54±18.32)分显著高于执行任务前(39.79±16.47)分,差异有统计学意义(t=2.74,P<0.01)。与执行任务前比较,执行任务后汽车兵SRQ各因子,STAI的状态焦虑、特质焦虑及TCSQ的消极应对因子分显著高于执行任务前,积极应对因子分显著低于执行任务前,差异均有统计学意义(P<0.05)。与执行任务前比较,执行任务后汽车兵血清IL-6、5-HT、CORT水平均升高,差异均有统计学意义(P<0.05)。结论急进高原执行任务作为强烈应激可导致汽车兵出现不良心理应激,并引起机体神经内分泌系统改变,对机体免疫能力产生一定的抑制。Objective To investigate the effects of rapidly entering tibet plateau on psychological stress,neuroendocrine and immune function of automobile soldiers,and to provide scientific basis for psychological stress protection of plateau automobile soldiers.Methods A random cluster sampling method was used to extract 106 automobile soldiers from a certain troop who carried out transportation tasks from a low-altitude environment to a high-altitude environment.Stress response questionnaire(SRQ),state-trait anxiety inventory(STAI)and trait coping style questionnaire(TCSQ)were used to evaluate psychological stress status at the time of before performing the mission(3 days before departure,in camp,with the altitude of 600 m)and when completing the mission(37 days after departure,in Tibetan area,with the altitude of 4 300 m).Blood was taken from 7:00 to 8:00 on the second day after psychological testing,and serum cortisol(CORT),serotonin(5-HT)and interleukin-6(IL-6)were measured by radioimmunoassay(RIA).Results After the execution of the mission,the SRQ total score(47.54±18.32)was significantly higher than that before the mission(39.79±16.47),t=2.74,P<0.01.After the execution of the mission,each factor of SRQ,state anxiety,trait anxiety,and negative coping factors scores were significantly higher than those before the mission,the positive coping factor score was significantly lower than that before the mission was performed,and the difference was statistically significant(P<0.05).Compared with before the execution of the task,the serum IL-6,5-HT and CORT levels of the autopilots increased after the execution of the task,and the differences were statistically significant(P<0.05).Conclusion Rapidly entering tibet plateau to implement the mission as a strong stress can lead to adverse psychological stress in the automobile soldiers,and cause changes in the neuroendocrine system of the body,which will inhibit the immunity of the body.

关 键 词：汽车兵 高海拔 应激 心理学 氢化可的松 血清素 血清白介素-6 

分 类 号：R949.44[医药卫生—药剂学]