荧光金属纳米簇的合成及其在生物医学中的应用研究进展  

Synthesis of Fluorescent Metal Nanoclusters and Their Biomedical Applications

作　　者：孙欢欢 卿太平[1] 步鸿昌 何晓晓[1] 王柯敏[1,2] SUN Huan-huan;QING Tai-ping;BU Hong-chang;HE Xiao-xiao;WANG Ke-min(College of Biology,Hunan University,Changsha 410082,China;College of Chemistry and Chemical Engineering,Key Laboratory for Bio-Nanotechnology and Molecule Engineering of Hunan Province,Hunan University,Changsha 410082,China)

机构地区：[1]湖南大学生物学院,湖南长沙410082 [2]湖南大学化学化工学院,湖南省生物纳米与分子工程重点实验室,湖南长沙410082

出　　处：《分析测试学报》2018年第10期1119-1129,共11页Journal of Instrumental Analysis

基　　金：国家自然科学基金资助项目(21675046，21735002)；湖南省重点研发计划实验动物重点研发项目(2017DK2011)

摘　　要：金属纳米簇作为一种新型的荧光纳米材料,展现出良好的生物相容性和优良的物化性质,近年来受到各个领域的关注,尤其在生物医学领域得到了广泛的应用。该文在介绍多种金属纳米簇的合成方法和光学性质的基础上,综述了金属纳米簇在生物传感、生物成像和肿瘤治疗等领域的应用研究进展,并对其面临的挑战和应用前景进行了展望。Fluorescent metal nanoclusters(MNCs),as novel fluorescent materials,exhibit good biocompatibility and excellent physicochemical properties,which have attracted more and more attention in various fields,especially in the biomedical field.In this review,the synthesis methods and optical properties of various metal nanoclusters are described.Then,the applications of metal nanoclusters in the biomedical field are reviewed from three aspects of biosensing,bioimaging and cancer therapy.Finally,the future challenges and application prospects of the MNCs in biomedical application are discussed.

关 键 词：金属纳米簇 生物医学应用 生物传感 生物成像 肿瘤治疗 

分 类 号：O652[理学—分析化学] TP212.3[理学—化学]