Hodgkin-Huxley神经元反转电势变化对动作电位的影响  

Effects of reversal potential on action potential based on Hodgkin-Huxley model

作　　者：易飞鸿 逯迈 陈凯 YI Feihong;LU Mai;CHEN Kai(Key Laboratory of Optoelectronic Technology and Intelligent Control(Ministry of Education),Lanzhou Jiaotong University,Lanzhou 730070,China;School of Automation and Electrical Engineering,Lanzhou Jiaotong University,Lanzhou 730070,China)

机构地区：[1]兰州交通大学光电技术与智能控制教育部重点实验室,甘肃兰州730070 [2]兰州交通大学自动化与电气工程学院,甘肃兰州730070

出　　处：《中国医学物理学杂志》2018年第10期1230-1235,共6页Chinese Journal of Medical Physics

基　　金：国家自然科学基金(51567015;51867014)

摘　　要：目的:运用数值模拟的方法研究离子通道反转电势参数变化对神经元发放动作电位的影响。方法:参考生理实验结果,运用Simulink软件分别对钠离子通道、钾离子通道和漏通道反转电势偏离标准值±10%、±20%、±30%下的Hodgkin-Huxley神经元模型进行建模,施加相同的刺激电流,得到神经元动作电位的响应结果。结果:3个通道的反转电势E_(Na)、E_K、E_l太小时,神经元不能正常发放连续的动作电位。在一定范围内增加时,E_(Na)、E_K、E_l都会使相同时间段内神经元动作电位的发放个数增加。并且当E_K变化导致神经元异常放电时,可以通过调节ENa来使神经元恢复正常放电。结论:离子通道反转电势的异变导致神经元的异常放电,这可能是离子通道疾病的病因。模拟结果表明离子通道疾病的治疗可以在多离子通道的参数调节上同时进行,这为其致病机理和临床治疗等研究提供了一定的思路和方法。Objective To investigate the effects of different ion channel reversal potential parameters on action potentials in neurons using numerical simulation.Methods With the reference of physiological experiment results,Simulink software was used to established Hodgkin-Huxley models of 3 ion channels(Na channel,K channel,and leakage channel)with reversal potentials deviating from the standard value of±10%,±20%and±30%.The same stimulation current was applied to obtain the response results of action potentials in neurons.Results The neurons were unable to generate continuous action potentials when the reversal potentials of 3 ion channels,namely ENa,EK and El,were too small.When increasing in a certain range,ENa,EK and El increased the number of action potentials in the same time period.When the changes of EK resulted in the abnormal discharge of neurons,the normal discharge could be restored by adjusting ENa.Conclusion The mutations of ion channel reversal potentials cause the abnormal discharge of neurons,which might be the reason of channelopathies.The simulation results show that the treatment of channelopathies can be carried out with the parameter adjustment of different ion channels at the same time,which provides some ideas and methods for the research of the pathogenesis and clinical treatment of channelopathies.

关 键 词：神经元 离子通道 反转电势 数值模拟 HODGKIN-HUXLEY 动作电位 

分 类 号：R338.8[医药卫生—人体生理学] Q811.2[医药卫生—基础医学]