失眠患者大脑功能变化的磁共振影像学研究进展  

Advances in magnetic resonance imaging of changes in brain function in patients with insomnia

作　　者：秦贺 刘波[1] 喻大华[2] QIN He;LIU Bo;YU Dahua(Department of Neurology,the First Affiliated Hospital of Baotou Medical College,Baotou 014010,China;Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing,Inner Mongolia University of Science and Technology,Baotou 014010,China)

机构地区：[1]包头医学院第一附属医院神经内科,内蒙古包头014010 [2]内蒙古科技大学内蒙古自治区模式识别与智能图像处理重点实验室,内蒙古包头014010

出　　处：《中国医学物理学杂志》2018年第9期1039-1042,共4页Chinese Journal of Medical Physics

基　　金：国家自然科学基金(81571753;81571751);内蒙古自治区高等学校青年科技英才支持计划(NJYT-17-B11)

摘　　要：失眠的脑功能改变一般先于脑实质的改变,而功能磁共振(fMRI)可以在生理状态下无创地反映不同脑区各自的功能状态。本文从失眠的静息态和任务态大脑功能变化两个方面,对失眠的fMRI研究进展进行综述。利用fMRI发现,在静息态方面,失眠患者的一些脑区的局部一致性值、低频振幅值等出现异常,功能连接出现改变;而在任务态方面,失眠患者在执行认知任务时,任务相关脑区的激活出现低水平活化。本文通过了解失眠的发病机制,以期将fMRI技术应用于失眠的临床诊断。For patients with insomnia,the changes in brain function are generally earlier than the structural changes of brain,and functional magnetic resonance imaging(fMRI)is a non-invasively technology to reflect the functional status of different brain regions under physiological conditions.Herein the research progress of fMRI in insomnia is reviewed from the aspects of the changes in resting-state or task-state brain functions.In resting state,regional homogeneity and amplitude of low-frequency fluctuation are found to be abnormal in several brain regions in patients with insomnia,and the functional connectivity is changed.When performing cognitive tasks,patients with insomnia show low-level activation of task-related brain regions.This review may help us understand the pathogenesis of insomnia and strive to apply fMRI technology in the clinical diagnosis of insomnia.

关 键 词：失眠 大脑功能 磁共振成像 综述 

分 类 号：R338.2[医药卫生—人体生理学] R445.2[医药卫生—基础医学]