金属铜盐催化活化α-氨基酮合成2-氧代-乙脒系列化合物  

Copper-Catalyzed Activation of α-Amino Ketones to Synthesize 2-Oxo-acetone Derivatives

作　　者：喻爱和[1] 陈志容 兰立新[3] YU Ai-he;CHEN Zhi-rong;LAN Li-xin(College of Chemistry and Chemical Engineering,Hunan Mechanical and Electrical Polytechnic College,Changsha 410151,China;Shuiguohu No.1 Middle School of Hubei Province,Wuhan 430071,China;Department of Pharmaceutical and Biological Engineering,Hunan Chemical Vocational Technology College,Zhuzhou 412004,China)

机构地区：[1]湖南机电职业技术学院化工学院,中国长沙410151 [2]湖北省水果湖第一中学,中国武汉430071 [3]湖南化工职业技术学院制药与生物工程学院,中国株洲412004

出　　处：《湖南师范大学自然科学学报》2018年第5期48-55,共8页Journal of Natural Science of Hunan Normal University

基　　金：湖南省自然科学基金资助项目(2018JJ2032);湖南省科技计划资助项目(2015WK3003)

摘　　要：通过铜的催化胺与α-氨基羰基化合物的氧化交叉偶联,实现了一种通用而温和的构建C—N键的方法.该方法适用于脂族伯胺、芳族伯胺或仲胺作为原料.当R2不同于R3时,可观察到两种异构体.该反应体系具有广泛的底物范围及温和的反应条件,为合成2-氧代-乙脒提供了一条简便高效的途径.In this work we report a general and mild method for the construction of carbon-nitrogen bond.Amines,either aliphatic primary amines,and aromatic primary amines or secondary amines were used as the starting materials.When R 2 was different from R 3,two isomers would be observed.In general,this reaction system has a broad substrate scope and provides a facile pathway for the synthesis of 2-oxo-acetamidines.

关 键 词：α-氨基羰基化合物 C-N键 异构体 2-氧代-乙脒 

分 类 号：TQ246.3[化学工程—有机化工]