尿液神经营养因子在筛查诊断及评估女性腺性膀胱中的应用探究  

Application of urine nerve growth factor in screening,diagnosis and postoperative evaluation of cystitis glandularis in female

作　　者：刘煜[1] 蒋远斌[1] 王铀[1] 王曦[1] 徐斌 郭宇[1] LIU Yu;JIANG Yuanbin;WANG You;WANG Xi;XU Bin;GUO Yu(Department of Urology,Hongqing Traditional Chinese Medicine Hospital,Chongqing 400021,China)

机构地区：[1]重庆市中医院泌尿外科,重庆400021

出　　处：《新疆医科大学学报》2018年第10期1223-1226,1230,共5页Journal of Xinjiang Medical University

基　　金：重庆市卫计委科研项目(2015MSXM078)

摘　　要：目的研究尿液神经营养因子与尿肌酐比值(NGF/Cr)在女性腺性膀胱炎(CG)患者、膀胱过度活动症(OAB)患者及正常人群(NC)中的表达差异,以及在CG患者手术治疗前后的差异,并探究NGF/Cr与OABSS评分在筛查诊断CG及评估CG疗效中的相关性。方法收集2015年9月—2017年11月期间本院就诊的43例OAB女性患者(OAB组)和同期就诊的37例CG女性患者(CG组)的病例资料,并选择同期47例无泌尿系统疾病及其他重大疾病的女性志愿者(NC组)作为对照组。分别检测OAB组、CG组及NC组研究对象尿液NGF/尿肌酐(NGF/Cr)水平和OAB症状评分(OABSS),同时检测CG组患者手术治疗前后尿液NGF/Cr水平和OABSS。结果 OAB组、CG组及NC组患者术前尿液NGF/Cr分别为(0.79±0.18)pg/mg、(0.86±0.09)pg/mg和(0.11±0.03)pg/mg,OABSS分别为(7.09±0.97)分、(7.27±0.87)分和(0.25±0.57)分。其中OAB组与CG组的尿液NGF/Cr差异具有统计学意义(P=0.038),OABSS差异无统计学意义(P=0.773)。CG组与NC组的尿液NGF/Cr、OABSS差异均具有统计学意义(P=0.000)。在OAB组及CG组中,尿液NGF/Cr与OABSS有明显相关性。CG组患者术前与术后尿液NGF/Cr分别为(0.86±0.09)pg/mg和(0.21±0.03)pg/mg,差异具有统计学意义(P=0.000)。OABSS分别为(7.27±0.87)分和(0.86±0.42)分,差异具有统计学意义(P=0.000)。尿液NGF/Cr与OABSS于术前及术后均呈现明显相关性。结论尿液NGF/Cr水平为筛查CG和鉴别诊断CG与OAB,以及评估CG的治疗效果提供了更安全无创、有效的方法。Objective To detect the differences of the ratio of urine nerve growth factor and urine creatinine(NGF/Cr)among the normal(NC)and patients with overactive bladder(OAB)and cystitis glandularis(CG),and investigate the variation of urine NGF between preoperative and postoperative patients with CG.And to further understand the relevance of urine NGF/Cr and OABSS score in screening,diagnosis and postoperative evaluation of CG in female.Methods In the period of time between September 2015 and November 2017,we totally collected 43 female patients with OAB,37 female patients with CG and 47 normal persons.The ages of them are(45.19±13.58)y,(46.73±12.20)y and(42.89±11.95)y in OAB group,CG group and NC group respectively.The levels of urine NGF/Cr and OABSS of every sample in OAB group,CG group,NC group,preoperative CG group and postoperative group were measured.Res-ults The levels of urine NGF/Cr in OAB group,CG group and NC group were(0.79±0.18)pg/mg,(0.86±0.09)pg/mg and(0.11±0.03)pg/mg respectively.The OABSS in OAB group,CG group and NC group were(7.09±0.97),(7.27±0.87)and(0.25±0.57)respectively.In the comparison of OAB group and CG group,there was significant difference in urine NFG/Cr(P=0.038),but no significant difference in OABSS(P=0.773).In the comparison of CG group and NC group,there were significant differences in urine NFG/Cr(P=0.000)and in OABSS(P=0.000).In OAB and CG groups,there were obvious correlation between urine NFG/Cr and OABSS.The levels of urine NGF/Cr in preoperative and postoperative CG groups were(0.86±0.09)pg/mg and(0.21±0.03)pg/mg with significant difference(P=0.000).The OABSS in preoperative and postoperative CG groups were(7.27±0.87)and(0.86±0.42)with significant difference(P=0.000).There was obvious correlation between urine NFG/Cr and OABSS in preoperative and postoperative CG groups.Conclusion The levels of urine NFG/Cr is a safer and more effective indicator to diagnose CG and evaluate the therapeutic effect of CG.

关 键 词：尿液神经营养因子 腺性膀胱炎 膀胱过度活动症 筛查 疗效评估 

分 类 号：R694[医药卫生—泌尿科学]