高尿酸血症合并高血糖人群危险因素的调查  

Investigation on risk factors of hyperuricemia combined with hyperglycemia

作　　者：张鹏程 陈程[2] 古丽夏提.麦麦提吐尔逊 艾力夏提.图如普 叶飞 史浩楠 王婷婷[1] ZHANG Pengcheng;CHEN Cheng;Gulixiati Maimaitituersun;Ailixiati Turupu;YE Fei;Shi Haonan;WANG Tingting(School of Public Health,Xinjiang Medical University,Urumqi 830011,China;Clinical Laboratory Center,People′s Hospital of Xinjiang Autonomous Region,Urumqi 830000,China)

机构地区：[1]新疆医科大学公共卫生学院,乌鲁木齐830011 [2]新疆维吾尔自治区人民医院临床检验中心,乌鲁木齐830000

出　　处：《新疆医科大学学报》2018年第10期1306-1308,1316,共4页Journal of Xinjiang Medical University

基　　金：新疆医科大学大学生创新计划(CX2017149);国家自然科学基金(81660140);国家自然科学基金(81860179);新疆维吾尔自治区自然科学基金(2017D001C183)

摘　　要：目的通过病例对照研究,调查高尿酸血症合并高血糖人群的相关危险因素。方法选择2018年2-6月在新疆维吾尔自治区人民医院进行体检及住院的人群528名。将确诊为高尿酸血症者合并高血糖的患者254名作为病例组,选择同期在该院体检未患高尿酸血症、糖尿病且无血缘关系、年龄构成没有差别的274名体检者为对照组,对纳入的研究对象进行流行病学调查、体格检查、生化指标测定,分析该人群患高尿酸血症合并高血糖的主要危险因素。结果对照组和病例组收缩压、舒张压、甘油三酯、总胆固醇、尿酸、血糖、糖化血清蛋白、尿素、肌酐及BMI等指标差异均有统计学意义(P<0.05)。病例组和对照组在饮酒、血脂紊乱、高血压、冠心病、心理压力以及肥胖影响因素方面的差异均有统计学意义(P均<0.05),吸烟影响因素差异无统计学意义(P>0.05)。肥胖、冠心病、血脂紊乱、高血压及饮酒是高尿酸血症合并高血糖患病的危险因素(P均<0.05),心理压力差异无统计学意义(P>0.05)。结论肥胖、冠心病、高血压、血脂紊乱以及饮酒均是高尿酸血症合并高血糖发病的危险因素。Objective To explore the risk factors of hyperuricemia with hyperglycemia by case-control study.Methods A total of 528 people were selected for physical examination and hospitalization in the Xinjiang Uygur Autonomous Region people's Hospital in February-June 2018,in which 254 patients with hyperuricemia and hyperglycemia were selected as the case group,while 274 healthy people without hyperuricemia,diabetes mellitus and blood relationship were as the control group.Epidemiological investigation,physical examination and biochemical indexes were carried out to analyze the main risk factors of hyperuricemia and hyperglycemia in the population.Results There were significant differences in systolic blood pressure,diastolic blood pressure,triglyceride,total cholesterol,uric acid,blood glucose,glycosylated serum protein,urea,creatinine and BMI between the control group and the case group(P<0.05).There were significant differences in drinking,dyslipidemia,hypertension,coronary heart disease,psychological stress and obesity between the two groups(P<0.05).But there was no significant difference in smoking factors between the two groups(P>0.05).Obesity,coronary heart disease,dyslipidemia,hypertension and alcohol consumption were risk factors for hyperuricemia complicated with hyperglycemia(P<0.05).And there was no significant difference in psychological stress(P>0.05).Conclusion Psychological stress,coronary heart disease,dyslipidemia and alcohol consumption are risk factors for hyperuricemia complicated with hyperglycemia.

关 键 词：高尿酸血症 高血糖 影响因素 

分 类 号：R587.1[医药卫生—内分泌] R589.7[医药卫生—内科学]