米索前列醇用于子宫壁间肌瘤术前预处理的疗效分析  

Effect of misoprostol for preoperative treatment in transcervical resection of uterine intramural myoma

作　　者：李灿宇[1] 杨敬敬[1] 郭欢欢[1] 申爱荣[1] 封全灵[1] Li Canyu;Yang Jingjing;Guo Huanhuan;Shen Airong;Feng Quanling(Department of Gynecology,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第三附属医院妇科,河南郑州450052

出　　处：《河南医学研究》2018年第19期3472-3474,共3页Henan Medical Research

基　　金：河南省卫生系统出国研修项目(2015060)

摘　　要：目的探讨米索前列醇用于宫腔镜子宫肌瘤电切(TCRM)术前预处理的疗效。方法选取2014年1月至2017年12月经郑州大学第三附属医院妇科收治的经宫腔镜治疗、病理确诊的90例单发子宫壁间内突肌瘤患者,分为单次用药组和重复用药组。单次用药组(于手术前2 h口服米索前列醇片400μg)共49例,其中Ⅰ型肌瘤29例,Ⅱ型肌瘤20例;重复用药组(于手术前晚及手术前2 h各口服米索前列醇片400μg) 41例,其中Ⅰ型肌瘤25例,Ⅱ型肌瘤16例。统计分析两组患者用药前后肌瘤内突的情况、手术时间、出血量和不良反应发生情况。结果在宫腔镜手术前口服米索前列醇片,无论对Ⅰ型肌瘤还是Ⅱ型肌瘤,重复用药较单次用药均增加肌瘤内突比例(P<0.05)、缩短手术时间(P<0.05)。两组出血量和不良反应发生率比较,差异无统计学意义(P>0.05)。结论在子宫黏膜下肌瘤宫腔镜电切术前重复口服米索前列醇可促进肌瘤内突,缩短手术时间,安全有效。Objective To investigate the effect of misprostol pretreated in transcervical resection of myoma(TCRM).Methods A total of 90 cases were recruited from January of 2014 to December of 2017 in the Third Affiliated Hospital of Zhengzhou University,who were diagnosed with single uterine intramural myoma by hysteroscopy and histology.These patients were divided into single dose group and repeated dose group.For single dose group(orally take misoprostol 400μg 2 h before TCRM),29 of the patients were typeⅠand 20 were typeⅡ.For repeated dose Group(orally take misoprostol 400μg the night before operation and 2 h before TCRM),25 of the patients were typeⅠand 16 were typeⅡ.The proportion change of myoma in uterine cavity before and after misoprostol use,blood lose and operation time between two groups were statistically analyzed.Results For typeⅠor typeⅡintramural myoma,repeated use of orally taken misoprostol significantly enhanced the proportion of myoma in uterine cavity(P<0.05),and shortened operation time than single dose use(P<0.05).There were no significant difference of blood lose and side-effects between two groups.Conclusion Pretreated with misoprostol repeatedly could effectively increase proportion of myoma in uterine cavity and shorten operation time in a safe manner.

关 键 词：子宫肌瘤 米索前列醇 宫腔镜电切术 

分 类 号：R737[医药卫生—肿瘤]