细菌纤维素在创面修复中的研究与应用特性  

Properties of bacterial cellulose in wound repair

作　　者：张卫佳 刘盈 Zhang Weijia;Liu Ying(School of Pharmacy,Xinhua College of Sun Yat-Sen University,Guangzhou 510000,Guangdong Province,China)

机构地区：[1]中山大学新华学院药学院,广东省广州市510000

出　　处：《中国组织工程研究》2018年第34期5565-5570,共6页Chinese Journal of Tissue Engineering Research

基　　金：广东普通高校教育科学"十二五"规划2014年项目(2014GXJK208):微课在高校<生物化学>教学中的应用研究~~

摘　　要：背景:细菌纤维素天然交织形成的超精细纳米级三维网络结构,已成为国内外新型生物医用材料的新方向。目的:通过总结细菌纤维素的原始组成和作为纳米材料等多种形式的应用,探讨其在生物医学领域的应用。方法:以"细菌纤维素,组织工程,医用材料,抗张强度"为中文关键词,以"Bacterial cellulose,tissue engineering,medical material,tensile strength"为英文关键词,检索CNKI、万方及PubMed、Medline数据库中有关细菌纤维素在创面修复中的应用研究的相关文献,总结细菌纤维素在创面修复中的应用现状,分析存在的问题及前景。结果与结论:细菌纤维素是由微生物分泌的一种高纯度、高结晶度的超细纳米纤维素,静置培养条件下可交织成多孔网络结构,其化学结构稳定、吸水性佳、透气性好、机械强度高、生物相容性良好,是理想的生物医用材料,特别在创面修复领域具有广泛的应用前景。目前已开发出细菌纤维素创面敷料产品,被证实能够促进组织再生和加速创面愈合。BACKGROUND:The ultra-fine nano-scale three-dimensional network structure formed by the natural interweaving of bacterial cellulose has become a new research direction of new biomedical materials.OBJECTIVE:To explore the application of bacterial cellulose in the biomedicine by summarizing the original composition and multiform of bacterial cellulose as a nanomaterial.METHODS:The keywords of“bacterial cellulose,tissue engineering,medical material,tensile strength”in Chinese and English were used to search CNKI,WanFang,PubMed and Medline databases for articles addressing the pro-vascularization of bacterial cellulose in wound repair.Then,the application of bacterial cellulose in wound repair was summarized,and the existing problems and prospects were also analyzed.RESULTS AND CONCLUSION:Bacterial cellulose secreted by the microorganism is of high purity and crystallinity.The nanofibers of bacterial cellulose form the porous network structure during static culture.It is considered as one of the ideal biomedical materials owing to its stable chemical structure,high water absorbency,good air permeability,great mechanical strength and biocompatibility.Especially in the field of wound repair,bacterial cellulose has been deeply studied and developed as the promising wound dressing,which is proven to promote tissue regeneration and accelerate wound healing.

关 键 词：细菌纤维素 创面修复 医用材料 抗张强度 杨氏模量 生物材料 纤维素 生物敷料 组织工程 

分 类 号：R318[医药卫生—生物医学工程]