肌肉减少症与代谢综合征关系的研究进展  

Progress in the relationship between muscle reduction and metabolic syndrome

作　　者：齐淑静[1] 齐瑞霞 张午临 张金风 孙宇航[1] 康艳辉[3] 李伟 付泽娴[1] 杨福申[1] 霍忠超[1] 卢佳慧[1] 于晓娟[1] 张宝霞[1] 任勇[1] 张瑞英[1] QI Shu-jing;QI Rui-xia;ZHANG Wu-lin;ZHANG Jin-feng;SUN Yu-hang;KANG Yan-hui;LI Wei;FU Ze-xian;YANG Fu-shen;HUO Zhong-chao;LU Jia-hui;YU Xiao-juan;ZHANG Bao-xia;REN Yong;ZHANG Rui-ying(Affiliated Hospital of Hebei University of Engineering,Handan 056002,Hebei,China;Handan Central Hospital,Handan 056000, Hebei,China;Medical College of Hebei University of Engineering,Handan 056002,Hebei,China)

机构地区：[1]河北工程大学附属医院,河北邯郸056002 [2]邯郸市中心医院,河北邯郸056000 [3]河北工程大学,河北邯郸056002

出　　处：《肿瘤代谢与营养电子杂志》2018年第3期324-327,共4页Electronic Journal of Metabolism and Nutrition of Cancer

基　　金：邯郸市科技局计划内项目(1623208061-3)

摘　　要：肌肉减少症是一种渐进性、全身性的综合征,属于增龄性疾病,主要表现为骨骼肌体积减少,肌力下降和机能减退。肌肉减少症不仅是机体运动系统衰老的一个表现,也是全身病理生理状态的反应。骨骼肌不仅是人体的运动系统,同时也是机体不可或缺的物质代谢器官,参与机体的分泌和代谢过程,如葡萄糖、糖原、脂质代谢及分泌多种细胞因子等。代谢综合征是以肥胖、糖代谢异常或糖尿病、高血压和血脂异常为主,多种代谢性疾病并存的一组临床症候群。老人由于体力活动水平下降和机体代谢能力下降,发生肌肉减少症的几率大大增加,进而导致代谢性疾病如高血脂、高血压、糖尿病等老年疾病频发。两者都与人体老化、代谢能力的下降密切相关,均属于年龄相关性疾病,由于代谢综合征并不是指一种疾病,因此研究代谢综合征与肌肉减少症之间的关系,本质是研究相关疾病与肌肉减少症之间的关系,本文将从两种疾病共同的病理基础、代谢异常角度对两者之间的关系进行综述。Sarcopenia is a progressive,systemic syndrome,which is an age-related disease,mainly manifests in the reduction of skeletal muscle mass,decreased muscle strength and function.Skeletal muscle is not only the movement system of human body,but also the body metabolism organ,which involves in the secretion and metabolism of the body,such as glucose,glycogen and lipid metabolism,secreting a variety of cytokines,etc.Metabolic syndrome is a group of clinical syndromes with multiple metabolic disease are mainly characterized by obesity,abnormal glucose metabolism or diabetes,hypertension and dyslipidemia.Due to physical activity levels falling and metabolism ability decreasing,the chance of muscle reduce disease has greatly increased in elder people,leading to metabolic diseases such as high cholesterol,high blood pressure,diabetes and other diseases of the elderly.The two diseases are both closely related to the declining ability of the human body aging,metabolism,and belong to age-related diseases.Because the metabolic syndrome is not a single disease,the research of the relationship between metabolic syndrome and reduce muscle diseases is truly studying the relationship between the related disease and reduce muscle disease.This article will interpret the relationship between the two diseases from both the common pathological basis and metabolic abnormality aspects.

关 键 词：肌肉减少症 代谢综合征 代谢异常 

分 类 号：R589[医药卫生—内分泌]