Preparation of porous Ta-10%Nb alloy scaffold and its in vitro biocompatibility evaluation using MC3T3-E1 cells  

多孔Ta-10%Nb支架制备及其体外生物性能评价（英文）

作　　者：Jing-lei MIAO Jue LIU Hui-feng WANG Hai-lin YANG Jian-ming RUAN 苗惊雷;刘珏;王汇丰;杨海林;阮建明(中南大学粉末冶金国家重点实验室,长沙410083;中南大学湘雅附属三医院骨科,长沙410013)

机构地区：[1]State Key Laboratory of Powder Metallurgy,Central South University,Changsha 410083,China [2]Department of Orthopedics,The Third Xiangya Hospital of Central South University,Changsha 410013,China

出　　处：《Transactions of Nonferrous Metals Society of China》2018年第10期2053-2061,共9页中国有色金属学报（英文版）

基　　金：Projects(51404302,51274247) supported by the National Natural Science Foundation of China;Project supported by "125 Talent Project" of the Third Xiangya Hospital of Central South University,China

摘　　要：A highly porous Ta-10%Nb alloy was successfully prepared for tissue engineering via the methods of the sponge impregnation and sintering techniques.The porous Ta-10%Nb alloy offers the capability of processing a pore size of 300-600μm,a porosity of(68.0±0.41)%,and open porosity of(93.5±2.6)%.The alloy also shows desirable mechanical properties similar to those of cancellous bone with the elastic modulus and the comprehensive strength of(2.54±0.5)GPa and(83.43±2.5)MPa,respectively.The morphology of the pores in the porous Ta-Nb alloy shows a good interconnected three-dimension(3D)network open cell structure.It is also found that the rat MC3T3-E1 cell can well adhere,grow and proliferate on the porous Ta-Nb alloy.The interaction of the porous alloy on cells is attributed to its desirable pore structure,porosity and the great surface area.The advanced mechanical and biocompatible properties of the porous alloy indicate that this material has promising potential applications in tissue engineering.通过海绵浸渍法和烧结技术制备得到组织工程用的高孔隙Ta-10%Nb支架材料,该材料的孔隙尺寸为300～600μm,孔隙率达到(68.0±0.41)%,同时开孔率高达(93.5±2.6)%。研究表明,制备得到的Ta-10%Nb支架材料具有与人体骨组织相似的弹性模量(2.54±0.5) GPa和抗压强度(83.43±2.5) MPa。同时,这种材料具有良好的三维空间结构单元,通过在该材料上进行鼠MC3T3-E1细胞共培养发现,细胞能很好地粘附生长和增殖。该材料所具备的良好生物力学性能和生物相容性能,使其在生物医学组织工程支架材料应用中具有良好的应用前景。这种多孔金属材料拥有良好的孔隙结构单元、适当的孔隙率以及大的表面积,使得该材料与细胞发生良好的作用。

关 键 词：porous Ta-Nb alloy low elastic modulus pore structure in vitro evaluation 

分 类 号：TB383.4[一般工业技术—材料科学与工程] R318.08[医药卫生—生物医学工程]