Ki-67和CK10在鼻腔鼻窦内翻性乳头状瘤中的表达及临床意义  

Expression and clinical significance of Ki-67 and CK10 in nasal inverted papilloma

作　　者：宋云韬 耿曼英[1] SONG Yuntao;GENG Manying(Department of Otorhinolaryngology,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou,He′nan 450000,China)

机构地区：[1]郑州大学第二附属医院耳鼻咽喉科,郑州450000

出　　处：《重庆医学》2018年第29期3766-3769,共4页Chongqing medicine

基　　金：河南省科技攻关项目(201702093;201303084)

摘　　要：目的探讨鼻腔鼻窦内翻性乳头状瘤(NIP)组织中Ki-67、细胞角蛋白10(CK10)的表达,分析其在NIP发生、发展及复发过程中的作用。方法应用免疫组织化学法检测50例NIP,20例鼻息肉(NP)及10例正常鼻腔黏膜(NM)组织中Ki-67和CK10的表达情况,并进行比较分析。结果 NM组、NP组和NIP组中CK10表达阳性率比较,差异有统计学意义(P<0.05);Ki-67表达阳性率在NIP组与NP组间比较,差异无统计学意义(P>0.05),在NIP和NM组间比较,差异有统计学意义(P<0.05);复发与未复发NIP患者Ki-67和CK10表达阳性率比较,差异有统计学意义(P<0.05);Krouse临床分级与组织中的Ki-67和CK10的表达无关(P>0.05);NIP患者Ki-67和CK10表达呈正相关(r=0.686,P<0.01)。结论 CK10在NIP的发生、发展中可能具有一定的作用,且可能与Ki-67具有协同作用。Objective To investigate the expression of Ki-67 and cytokeratin 10(CK10)in nasal inverted papilloma(NIP)of nasal cavity and sinus,and analyze their role in the occurrence,development and recurrence of NIP.Methods The expression of Ki-67 and CK10 were detected by immunochemistry in 50 cases of NIP,20 cases of nasal polyps(NP)and 10 cases of normal nasal cavity mucosa(NM),and comparative analysis was conducted.Results The significant difference of the positive rate of CK10 expression was found in the NM group,the NP group and the NIP group(P<0.05).There was statistically significant difference of the positive rate of Ki-67 expression between the NIP group and the NM group(P<0.05),while no significant difference was found between the NIP group and the NP group(P>0.05).Statistically significant differences were found in the positive rates of CK10 and Ki-67 expression between NIP patients with and without recurrence(P<0.05).There was no relationship between Krouse stage and the expression of Ki-67 and CK10(P>0.05).The expression of Ki-67 was positively correlated with the expression of CK10 in patients with NIP(r=0.686,P<0.01).Conclusion CK10 may play a certain role in the occurrence and development of NIP,and have synergistic effect with Ki-67.

关 键 词：鼻内翻性乳头状瘤 KI-67 细胞角蛋白10 复发 

分 类 号：R765.6[医药卫生—耳鼻咽喉科]