哌嗪及其N-取代衍生物的合成与生产  

Synthesis and manufacture of piperazine and its N-substituted derivatives

作　　者：白国义[1] 董洁 BAI Guoyi;DONG Jie(College of Chemistry and Environmental Science,Hebei University,Baoding 071002,China)

机构地区：[1]河北大学化学与环境科学学院,河北保定071002

出　　处：《河北大学学报（自然科学版）》2018年第5期472-479,共8页Journal of Hebei University(Natural Science Edition)

基　　金：国家自然科学基金资助项目(20376057)

摘　　要：重点介绍了哌嗪及其N-取代衍生物的合成路线和国内生产现状.哌嗪可采用N-β-羟乙基乙二胺、二乙烯三胺、乙二胺、乙醇胺等原料合成,其中以N-β-羟乙基乙二胺为原料的路线是目前哌嗪最高效的合成路线.哌嗪N-取代衍生物可以通过哌嗪和N-烷基化试剂反应或相应的伯胺与环氧乙烷、氨气等环合来合成.因哌嗪及其N-取代衍生物的应用范围广且用量大,进行该类化合物的合成与生产具有很好的发展前景.The main synthetic route and domestic manufacture of piperazine and its major N-substituted derivatives were reviewed in this paper.Piperazine can be synthesized by using N-β-hydroxyethyl ethylenediamine,diethylenetriamine,ethylenediamine,ethanolamine and other raw materials.Among them,the route using N-hydroxyethyl ethylenediamine as the starting material is believed as the most efficient route for the synthesis of piperazine.N-substituted derivatives of piperazine can be synthesized via either piperazine and N-alkyl agents or related primary amines,ethylene oxide and ammonia.Synthesis and manufacture of piperazine and its N-substituted derivatives have broad prospects of development due to their wide application areas and huge demand.

关 键 词：哌嗪 衍生物 N-β-羟乙基乙二胺 

分 类 号：O62[理学—有机化学]