三维石墨烯/L-胱氨酸复合物修饰电极的制备及对氯氮平的测定  

Preparation of three-dimensional graphene/L-CysS composite modified electrode and its application in determination of clozapine

作　　者：梁宁刚 李娟娟[1] 蔡卓[1] 蒋翠文[1] 叶丹妮[1] LIANG Ninggang;LI Juanjuan;CAI Zhuo;JIANG Cuiwen;YE Danni(School of Chemistry and Chemical Engineering,Guangxi University,Nanning 530004,China)

机构地区：[1]广西大学化学化工学院,广西南宁530004

出　　处：《河北大学学报（自然科学版）》2018年第5期503-508,共6页Journal of Hebei University(Natural Science Edition)

基　　金：广西自然科学基金资助项目(2015GXNSFAA139239)

摘　　要：采用滴涂法制备三维石墨烯/L-胱氨酸复合物修饰电极(3DGR/L-CysS/GCE),并用电化学交流阻抗谱(EIS)和扫描电镜(SEM)对电极材料进行表征.以循环伏安法(CV)、恒电位库伦分析法(CPC)、差分脉冲伏安法(DPV)和计时电量法(CC)研究了氯氮平在该修饰电极上的电化学行为.实验结果表明:在pH6.8的Na_2HPO_4-NaH_2PO_4溶液中,氯氮平在3DGR/L-CysS/GCE上是单电子和单质子转移的电化学反应,在2.0×10-5~5.0×10-4 mol/L浓度内,氧化峰电流与氯氮平的线性关系良好,其检出限(S/N=3)为1.21×10^(-6) mol/L.样品测定的回收率为97.5%~100.8%.The 3DGR/L-CysS/GCE was prepared by drop-coating method,and characterized by electrochemical impedance spectroscopy(EIS)and scanning electron microscopy(SEM).The electrochemical behaviors of clozapine at 3DGR/L-CysS/GCE were studied by cyclic voltammetry(CV),controlled potential coulometry(CPC),differential pulse voltammetry(DPV)and chronocoulometry(CC).The experimental results showed that the reaction of clozapine at 3DGR/L-CysS/GCE was an electrochemical reaction with one electron and one proton transfer.The peak current and clozapine content showed a good linear relationship in the concentration range of 2.0×10-5~5.0×10-4 mol/L,and the detection limit was 1.21×10-6 mol/L(S/N=3).3DGR/L-CysS/GCE was used for the determination of clozapine in tablets,and the recovery was 97.5%~100.8%.

关 键 词：修饰电极 L-胱氨酸 三维石墨烯 氯氮平 

分 类 号：O657.1[理学—分析化学] R914[理学—化学]