迷走复合体和迷走神经在炎症反应中的可塑性  

Plasticity of Dorsal Vagal Complex and Vagus Nerve in Inflammatory Response

作　　者：李霞 赵盼 王天霞 孙海基[2] LI Xia;ZHAO Pan;WANG Tianxia;SUN Haiji(College of Environmental Science and Engineering,Shandong Agricultural and Engineering University,Jinan 250100,China;College of Life Science,Shandong Normal University,Jinan 250014,China)

机构地区：[1]山东农业工程学院环境科学与工程学院,山东济南250100 [2]山东师范大学生命科学学院,山东济南250014

出　　处：《济南大学学报（自然科学版）》2018年第6期487-491,共5页Journal of University of Jinan(Science and Technology)

基　　金：国家自然科学基金项目(31672286);山东省自然科学基金项目(ZR2013CM010)

摘　　要：为了探究炎症反应过程中孤束核-迷走神经背核-迷走神经的可塑性变化,实验分内毒素脂多糖(LPS)组和对照组2组,LPS组大鼠股静脉注射LPS,对照组大鼠股静脉注射同体积的生理盐水,测定迷走神经放电频率、血压、血清肿瘤坏死因子α(TNF-α)水平以及孤束核和迷走神经背核内Fos阳性神经元表达情况。结果表明:LPS注射后,迷走神经放电频率明显增大,血压虽有降低但不明显;与对照组相比,LPS组神经放电频率明显增大,血清TNF-α水平显著升高,孤束核和迷走神经背核的Fos表达均显著增强,说明迷走神经和孤束核、迷走神经背核参与了炎症反应。To explore plasticity changes of the nucleus tractus solitarious-dorsal motor nucleus of vagus-vagus nerve pathway in inflammatory response,the experiment was divided into two groups of lipopolysaccharide(LPS)group and control group.The rats in LPS group were vena femoralis injected LPS and the rats in control group were vena femoralis injected saline of the same volume.The frequency of vagus nerve discharge,arterial pressure,tumor necrosis factorα(TNF-α)levels as well as Fos positive neurons express in the nucleus tractus solitarious and dorsal motor nucleus of vagus were measured.The results show that compared with before LPS injection,the discharge frequency of the vagus nerve increases significantly after LPS injection,and the blood pressure decreases but not significant.Comparing with the control group,the frequency of vagus nerve discharge,serum TNF-αlevel,Fos expressionofbrain stem of nucleus tractus solitarious,and dorsal motor nucleus of vagus solitary enhance significantly in LPS group,which shows that the vagus nerve,nucleus tractus solitarious,and the dorsal motor nucleus of the vagus are involved in the inflammatory response.

关 键 词：迷走复合体 FOS表达 迷走神经 内毒素 炎症反应 

分 类 号：Q955[生物学—动物学]