磁共振成像定量灌注参数评价子宫肿瘤血管生成的研究进展  

Evaluation of Uterine Tumor Angiogenesis with Quantitative Magnetic Resonance Imaging Perfusion Parameters

作　　者：徐阿巧 赵振华[2] 杨建峰[2] 韦明珠[2] 郑静 鲁君敏 胡红杰[3] 张盛箭 XU Aqiao;ZHAO Zhenhua;YANG Jianfeng;WEI Mingzhu;ZHENG Jing;LU Junmin;HU Hongjie;ZHANG Shengjian(Department of Radiology,Shaoxing Central Hospital,Shaoxing,Zhejiang 312030,China;Department of Radiology,Shaoxing People’s Hospital,Shaoxing,Zhejiang 312000,China;Department of Radiology,Sir Run Run Shaw Hospital Affiliated to Medical College of Zhejiang University,Hangzhou 310000,China;Department of Radiology,Tumor Hospital Affiliated to Fudan University,Shanghai 200032,China)

机构地区：[1]中国医科大学绍兴医院绍兴市中心医院放射科,浙江绍兴312030 [2]绍兴市人民医院放射科,浙江绍兴312000 [3]浙江大学医学院附属邵逸夫医院放射科,杭州310000 [4]复旦大学附属肿瘤医院放射科,上海200032

出　　处：《中国医学科学院学报》2018年第5期705-709,共5页Acta Academiae Medicinae Sinicae

基　　金：浙江省科技厅公益技术研究社会发展项目(2014C33151);浙江省医药卫生一般研究计划项目(2014KYA215;2015RCA024和2015KYB402)~~

摘　　要：子宫肿瘤的发展和转移依赖于肿瘤血管生成。多期动态增强磁共振成像定量分析可根据多种已知的药物动力学模型,采用时间-信号曲线进行分析,模拟出血管(血浆)内外对比剂的分布规律和交换过程,从而定量描述出血流动力学的变化情况,所获得的功能参数能准确无创地评估肿瘤血管生成状态,为子宫肿瘤良恶性鉴别、分期、疗效评估及预后判断提供帮助。The development and metastasis of uterine tumors depend highly on tumor angiogenesis.Multiphase dynamic contrast-enhanced magnetic resonance imaging can quantitatively describe the hemodynamic changes of uterine tumors based on a variety of tracer kinetic models and time-signal curves and by simulating the distribution of contrast inside and outside the blood vessels.Functional parameters can accurately and noninvasively assess tumor angiogenesis.It provides a non-invasive functional evaluation method for the differential diagnosis,staging,response evaluation,and prognostic prediction of uterine tumors.

关 键 词：磁共振成像 子宫肿瘤 微血管密度 血管内皮生长因子 

分 类 号：R445.2[医药卫生—影像医学与核医学]