二氧化硅-共聚物杂化荧光纳米材料用于动物活体成像  

Silica-Copolymer Hybrid Nanocomposite for Animal Bioimaging

作　　者：张泽芳 袁薇 徐明[2] 易韬 张善端[1] 李富友[2] ZHANG Ze-Fang;YUAN Wei;XU Ming;YI Tao;ZHANG Shan-Duan;Li Fu-You(Engineering Research Center of Advanced Lighting Technology,Ministry of Education,Fudan University,Shanghai 200433,China;Department of Chemistry,Fudan University,Shanghai 200433,China;Department of Integrative Medicine,Huashan Hospital,Fudan University,Shanghai 200040,China)

机构地区：[1]复旦大学先进照明技术教育部工程研究中心,上海200433 [2]复旦大学化学系,上海200433 [3]复旦大学附属华山医院中西医结合科,上海200040

出　　处：《无机化学学报》2018年第11期1943-1949,共7页Chinese Journal of Inorganic Chemistry

基　　金：国家重点基础研究发展计划(No.2017YFA0205100)项目资助

摘　　要：以氧化硅(SiO_2)前驱体与三嵌段共聚物F108合成较小粒径的SiO_2-共聚物杂化纳米体系(SNP),并与高效近红外发射的疏水染料M507自组装,构建了近红外发光纳米探针M507@SNP。同时,研究了M507@SNP的光物理性能和细胞毒性。动物成像实验证明该纳米成像探针可实现活体层次高信噪比的小动物全身成像和前哨淋巴结的指示。Near-infrared nanometer probe(M507@SNP)is obtained by monomer self-assembly between silica precursor and triblock copolymer F108 and then doping hydrophobic near-infrared dye M507.The photophysical properties and cytotoxicity of M507@SNP are investigated.Furthermore,M507@SNP is used as a fluorescent nanoprobe for monitoring whole-body and sentinel lymph node of rodents with high signal-to-noise.

关 键 词：杂化复合材料 荧光成像 空心二氧化硅粒子 近红外荧光染料 

分 类 号：O613.72[理学—无机化学]