神经炎症介导运动调控阿尔茨海默病的机制研究  

The Research of Neuroinflammatory-mediated Exercise Regulating the Mechanism of Alzheimer's Disease

作　　者：余锋[1] 贾芳芳 徐帅 江海洋 王贤 YU Feng;JIA Fang-fang;XU Shuai;JIANG Hai-yang;WANG Xian(School of Physical Education,Huaiyin Normal University,Huai’an 223300,China;The 82nd Hospital of PLA,Huai’an 223300,China)

机构地区：[1]淮阴师范学院体育学院,江苏淮安223300 [2]解放军第八二医院,江苏淮安223300

出　　处：《南京体育学院学报》2018年第4期33-40,74,共9页Journal of Nanjing Sports Institute

基　　金：淮阴师范学院博士科研启动基金项目(项目编号:31YF001);江苏省高校自然科学基金(项目编号:16KJD180001)

摘　　要：阿尔茨海默病(Alzheimer’s disease,AD)是神经功能退行性疾病。AD的发生、发展可导致患者生活质量下降和病死率升高,其发病机制尚不明确。但研究发现,慢性神经炎症是AD发病的重要病理特征,如果起病阶段的急性炎症得不到控制,急性炎症将发展为慢性炎症,最终导致疾病恶化。慢性炎症由非特异性激活的神经胶质细胞引起,并对其周围的神经元和其他胶质细胞产生危害,进而诱导AD等神经系统疾病的发生。而运动对促进身体和脑的健康具有重要作用,研究发现,运动可通过改善神经胶质细胞介导的神经免疫反应和调节CNS的炎症状态,以及运动通过调节肌细胞因子和犬尿氨酸介导的神经炎症,进而抑制脑疾病的发生。研究综述了运动改善神经炎症的机制,分析神经炎症介导的运动预防和缓解AD的可能机制。Alzheimer’s disease(AD)is a neurodegenerative disease,which increasingly contributes to mortality of human.Although the pathogenic mechanism of AD is quite diverse,chronic neuroinflammation is the feature of AD.Even though the specific root causes of these diseases remain unknown,evidence indicates that neuroinflammation is the pathological feature of AD.If the initial acute inflammation is not resolved,a chronic neuroinflammatory state develops and ultimately contributes to the disease progression.Chronic neuroinflammation is characterized by non-specific activation of glial cells,which can lead to collateral damage of nearby neurons and other glial cells.This misdirected neuroinflammatory response is contribute to neuropathology in AD.Exercise is important for maintenance whole body and brain health,may also beneficially modify neuroimmune responses.Exercise has neuroimmune-modifying properties,and chronic neuroinflammation is the feature of AD.The study found that exercise could remit brain diseases by modifying glia-mediated neuroinflammation,regulating of the inflammatory state of CNS,and also exercise by regulating myokines and kynurenine which mediated neuroinflammation.This review focus on current evidence that supporting the disease-altering potential of exercise through modifications of neuroinflammation responses,and analyzing the possible mechanism of neuroinflammation mediated exercise preventing and mitigating AD.

关 键 词：神经炎症 神经胶质细胞 运动 中枢神经系统 阿尔茨海默病 

分 类 号：G804.5[文化科学—运动人体科学]