维吾尔族高血压病病人血尿酸水平与高血压及动脉硬化的关系研究  

Relationship between Serum Uric Acid Level and Hypertension and Arteriosclerosis in Uygur Patients

作　　者：王淑霞 周怡 Wang Shuxia;Zhou Yi(Urumqi First People′s Hospital,Urumqi 830011,Xinjiang,China)

机构地区：[1]乌鲁木齐市第一人民医院,乌鲁木齐830011 [2]喀什地区第二人民医院

出　　处：《中西医结合心脑血管病杂志》2018年第19期2847-2850,共4页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的探讨维吾尔族高血压病病人血尿酸(SUA)水平与高血压及动脉硬化的关系。方法选择2014年3月—2016年9月我院收治的维吾尔族高血压病人106例作为研究组,另外选择同期于我院进行健康体检的志愿者85名作为对照组。比较所有受试者的SUA水平、血压、颈动脉膜中层厚度(IMT)值及血脂水平,同时对比不同高血压分级及不同IMT分级病人的SUA水平,分析SUA与检测指标之间的相关性。结果与对照组相比,研究组病人SUA、收缩压(SBP)、舒张压(DBP)及脉压(PP)、IMT、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平明显升高(P <0.05),而高密度脂蛋白胆固醇(HDL-C)水平降低(P <0.05);3级高血压病人的SUA、SBP、DBP及PP水平均明显高于1级和2级高血压病人(P <0.05),而2级高血压病人各项指标高于1级高血压病人(P <0.05);不同IMT分级的高血压病人SUA、TC、TG、LDL-C及HDL-C水平之间差异有统计学意义(P <0.05),与IMT正常病人相比,颈动脉硬化病人和颈动脉斑块病人的SUA、TC、TG及LDL-C水平明显升高,而HDL-C水平显著降低,同时除HDL-C外,颈动脉斑块病人的SUA及血脂指标明显高于颈动脉硬化病人,且差异均具有统计学意义(P <0.05);高血压病人SUA水平与SBP、DBP、PP、IMT、TC、TG及LDL-C呈正相关(P <0.05),而与HDL-C呈负相关(P <0.05)。结论维吾尔族高血压病人血压、血脂及SUA水平高于健康人群,随着高血压分级和动脉粥样硬化严重程度的增加,SUA水平升高,SUA对于维吾尔族高血压病人的诊断具有重要意义。Objective To investigate the relationship between serum uric acid(SUA)level and hypertension and arteriosclerosis in Uygur patients.Methods One hundred and six patients with hypertension in our hospital from March 2014 to September 2016 were selected as the research group.Eighty five healthy individuals were as control group.The levels of SUA,blood pressure,intima media thickness(IMT),and related parameters of blood lipid were compared.At the same time,the levels of SUA were compared in patients with different hypertension grades and IMT grades.The correlation between SUA and testing indexes were analyzed.Results Compared with control group,the levels of SUA,systolic blood pressure(SBP),diastolic blood pressure(DBP),pulse pressure(PP),carotid intima media thickness(IMT),total cholesterol(TC),triglyceride(TG)and low density lipoprotein cholesterol(LDL C)increased in research group(P<0.05),while the level of high density lipoprotein cholesterol(HDL C)obviously decreased(P<0.05).The levels of SUA,SBP,DBP,and PP in patients with grade 3 hypertension were significantly higher than those in patients with grade 1 and grade 2 hypertension(P<0.05).The level of each index in patients with grade 2 hypertension was significantly higher than that in patients with grade 1 hypertension(P<0.05).There were differences in the levels of SUA,TC,TG,LDL C,and HDL C among hypertension patients with different IMT level(P<0.05).Compared with normal IMT patients,the levels of SUA,TC,TG and LDL C were significantly increased in patients with carotid atherosclerosis and carotid plaques,while HDL C level significantly reduced.The levels of SUA,TC,TG and LDL C in patients with carotid plaques were obviously higher than those in patients with carotid atherosclerosis(P<0.05).The level of SUA was positively correlated with SBP,DBP,PP,IMT,TC,TG,and LDL C in patients with hypertension(P<0.05),and negatively correlated with HDL C(P<0.05).Conclusion The blood pressure,blood lipids and SUA levels of Uygur patients with hypertension are different from

关 键 词：高血压病 血尿酸 动脉硬化 血脂 维吾尔族 颈动脉内膜中层厚度 

分 类 号：R544.1[医药卫生—心血管疾病] R256.2[医药卫生—内科学]