早期膝骨关节炎患者血清雌二醇和睾酮水平与病变程度的关系  

Correlation between serum estradiol and testosterone levels and severity of early-stage knee osteoarthritis in patients

作　　者：黄捷 薄占东[2] 刘刚 罗世兴 Huang Jie;Bo Zhandong;Liu Gang;Luo Shixing(the Second Affiliated Hospital of Guangxi Medical University,Nanning 530007,Guangxi Zhuang Autonomous Region,China;the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,Guangxi Zhuang Autonomous Region,China;Fourth Affiliated Hospital of Guangxi Medical University,Liuzhou 545005,Guangxi Zhuang Autonomous Region,China;the Ninth Affiliated Hospital of Guangxi Medical University,Beihai 536000,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]广西医科大学第二附属医院,广西壮族自治区南宁市530007 [2]广西医科大学第一附属医院,广西壮族自治区南宁市530021 [3]广西医科大学第四附属医院,广西壮族自治区柳州市545005 [4]广西医科大学第九附属医院,广西壮族自治区北海市536000

出　　处：《中国组织工程研究》2018年第36期5760-5765,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(81460345)~~

摘　　要：背景:研究表明膝关节骨关节炎绝经后女性的患病率更明显高于同龄段男性,根据膝关节骨关节炎特殊的发病年龄和性别提示性激素水平与膝关节骨关节炎的发病机制可能有密切相关性。目的:在早期的膝关节骨关节炎患者中,探索绝经后女性和同龄男性的血清中性激素水平与膝关节骨关节炎严重程度的相关性。方法:采集膝关节骨关节炎患者44例和正常人29例,共73例,按性别差异分为绝经后女性组(n=37)和对应年龄段男性组(n=36),两组再参照Kellgren-Lawrence(K-L)分级标准,分为K-L0级、Ⅰ级、Ⅱ级3个亚组。采用电化学发光法检测各组血清中的雌二醇和睾酮水平,分别关联受试者的K-L分级,分析其与K-L分级的相关性。结果与结论:(1)在绝经后女性膝关节骨关节炎患者中,K-L分级0级与Ⅰ级者血清中雌二醇的水平差异无显著性意义(P> 0.05),0级、Ⅰ级分别与Ⅱ级的血清中雌二醇水平差异有显著意义(P <0.05);(2)绝经后女性膝关节骨关节炎按K-L分级0级、Ⅰ级、Ⅱ级的血清中睾酮水平两两比较差异均无显著性意义(P> 0.05);(3)绝经后女性膝关节骨关节炎严重程度与血清雌二醇水平呈现出明显的负相关性(r_s=-0.709, P <0.05),与血清睾酮水平无明显相关性(P> 0.05);(4)在对应年龄段男性膝关节骨关节炎患者中,K-L分级0级与Ⅰ级的血清中雌二醇水平和睾酮差异均无显著意义(P> 0.05),0级、Ⅰ级分别与Ⅱ级的血清中雌二醇和睾酮水平差异均有显著意义(P <0.05);(5)对应年龄段男性膝关节骨关节炎严重程度与血清雌二醇水平(r_s=-0.476,P<0.05)和睾酮水平(r_s=-0.418,P<0.05)均呈现出明显的负相关性;(6)结果提示,绝经后女性早期膝关节骨关节炎严重程度与血清中雌二醇水平存在负相关;对应年龄段的男性早期膝关节骨关节炎严重程度与血清中雌二醇和睾酮水平均存在负相关。BACKGROUND:The incidence of knee osteoarthritis(KOA)in postmenopausal females has been found to be higher than that in the males of the same age.The age and gender distribution suggests that there exists certain correlation between KOA pathogenesis and sex hormone levels.OBJECTIVE:To explore the correlation between sex hormone levels of the postmenopausal females and males of the same age,and early-stage KOA severity.METHODS:Forty-four KOA patients and 29 healthy people were enrolled.The subjects were divided into two groups by sex,including postmenopausal female group(n=37)and male group age(n=36).Each group was further subdivided by Kellgren-Lawrence K-L grading system,including subgroups of K-L 0,K-L I and K-L II.The serum estradiol and testosterone levels in each subgroup were detected by electrochemical luminescence method,and its association with K-L grade was analyzed.RESULTS AND CONCLUSION:In the postmenopausal female KOA patients,the serum estradiol level showed no significant difference between K-L 0 and K-L I subgroups(P>0.05),the level in the K-L 0 and K-L I subgroups showed significant difference compared with the K-L II subgroup(P<0.05).The serum testosterone level showed no significant difference among groups in the postmenopausal female KOA patients(P>0.05).The KOA severity showed a negative correlation with the serum estradiol level(rs=-0.709,P<0.05)but no correlation with the serum testosterone(P>0.05).In the male KOA patients,the serum estradiol and testosterone levels showed no significant difference between K-L 0 and K-L I subgroups(P>0.05),the levels in the K-L 0 and K-L I subgroups showed significant difference compared with the K-L II subgroup(P<0.05).The KOA severity in male KOA patients showed a negative correlation with the serum estradiol level(rs=-0.476,P<0.05)and serum testosterone level(rs=-0.418,P<0.05).These results indicate that the severity of early-stage KOA shows a negative correlation with the serum estradiol level in the postmenopausal female patients and a negative correlat

关 键 词：膝骨关节炎 早期 血清 性激素 男性 女性 雌二醇 睾酮 K-L分级 国家自然科学基金 

分 类 号：R318[医药卫生—生物医学工程]