骨组织工程研究中P75神经营养因子受体的作用及应用价值  

Roles and application values of P75 neurotrophin receptor in bone tissue engineering

作　　者：沈梦杰 杨琨[1] 刘琪[1] Shen Mengjie;Yang Kun;Liu Qi(Department of Periodontology,Stomatological Hospital Affiliated to Zunyi Medical University,Zunyi 563003,Guizhou Province,China)

机构地区：[1]遵义医学院附属口腔医院牙周科,贵州省遵义市563003

出　　处：《中国组织工程研究》2018年第36期5852-5857,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(81760199)~~

摘　　要：背景:P75神经营养因子受体属于低亲和力神经营养因子受体,它不仅在神经生长、发育和维持功能完整性等方面具有重要作用,而且与骨组织修复、增强干细胞特性等方面也密切相关。目的:对目前P75神经营养因子受体在骨组织修复及再生中的研究进展以及价值进行综述。方法:计算机检索中国生物医学文献数据库、CNKI数据库、PubMed数据库以及Elsevier数据库的相关文献,检索词为"骨修复,骨再生,P75,P75NTR,bone repair,bone regenerate,tooth development,facialnerve,stemcell"。查阅1987年9月至2018年4月期间收录的P75神经营养因子受体在骨组织再生修复方面的相关文章,最终纳入47篇文献进行结果分析。结果与结论:(1)研究报道P75神经营养因子受体能促进牙齿的发育和面神经的修复,促进骨组织的矿化和缩短骨愈合的时间,还能通过调节干细胞的特性来间接促进骨愈合;(2)也有研究者认为P75神经营养因子受体诱导的细胞凋亡可能会阻碍骨折的愈合,甚至导致骨折不愈合;(3)对于P75神经营养因子受体在骨组织修复方面所表现出双重作用的通路机制,未来还需要更深入的研究;(4)目前关于P75神经营养因子受体在骨组织修复的研究还仅仅局限于基础研究,临床应用的报道还很少。BACKGROUND:P75 neurotrophin receptor holds low affinity,which not only plays an important role in nerve growth,development and maintenance of functional integrity,but also has a close relationship with bone tissue repair and stem cell enhancement.OBJECTIVE:To review the research progress and value of P75 neurotrophin receptor in bone tissue repair and regeneration.METHODS:A computer-based search of CBM,CNKI,PubMed and Elsevier was performed for retrieving articles concerning P75 neurotrophin receptor in bone tissue regeneration published from September 1987 to April 2018.The keywords were“P75,P75NTR,bone repair,bone regenerate,tooth development,facial nerve,stem cell”in Chinese and English,respectively.Totally 47 eligible articles were included in final analysis.RESULTS AND CONCLUSION:P75 neurotrophin receptor has been reported to not only promote tooth development and facial nerve repair,but also promote mineralization of bone tissue and shorten bone healing time.It also indirectly promotes bone healing by regulating the characteristics of stem cells.However,some researchers believe that apoptosis induced by P75 neurotrophin receptor may hinder fracture healing and even lead to fracture failure.Whether P75 neurotrophin receptor can promote bone repair or inhibit bone tissue repair needs further investigation.At present,its research is still limited to basic research,and there are few reports on its clinical application.

关 键 词：骨修复 P75神经营养因子受体 P75NTR 干细胞 骨组织工程 成骨 牙发育 面神经 再生 组织构建 

分 类 号：R318[医药卫生—生物医学工程]