血必净注射液联合乌司他丁注射液治疗脓毒血症的临床可行性研究  

Clinical feasibility study of Xuebijing Injection combined with Ulinastatin Injection in the treatment of pyemia

作　　者：陈维生[1] 钟耀区[2] 曾景 黄东伟 CHEN Wei-sheng;ZHONG Yao-qu;ZENG Jing(Emergency Intensive Care Unit,The Third People’s Hospital of Huizhou City,Huizhou 516000,China)

机构地区：[1]惠州市第三人民医院EICU,516000 [2]惠州市第三人民医院ICU,516000

出　　处：《中国现代药物应用》2018年第20期76-77,共2页Chinese Journal of Modern Drug Application

摘　　要：目的探讨血必净注射液联合乌司他丁注射液治疗脓毒血症的临床可行性。方法 90例脓毒血症患者作为研究对象,根据治疗方法不同分为观察组与对照组,各45例。观察组应用血必净注射液联合乌司他丁注射液治疗,对照组仅应用血必净注射液治疗,比较两组患者的临床疗效、机械通气时间、住院时间以及治疗前后白细胞计数、C反应蛋白、急性生理功能评分(SOFA)和并发症指标。结果治疗后,观察组总有效率为84.44%,高于对照组的66.67%,差异有统计学意义(P<0.05);观察组机械通气时间(10.51±1.31)、住院时间(13.51±2.11)d均短于对照组的(14.29±2.27)、(18.49±3.04)d,差异有统计学意义(P<0.05);观察组白细胞计数(6.71±0.03)×10~9/L、C反应蛋白(22.62±0.15)mg/L、SOFA评分(1.01±0.11)分优于对照组的(11.29±0.13)×10~9/L、(52.41±0.20)mg/L、(2.01±0.11)分,差异均有统计学意义(P<0.05)。两组患者均未出现并发症。结论血必净注射液联合乌司他丁注射液治疗脓毒血症的效果确切,可有效改善临床症状,降低炎症水平,安全有效,值得推广应用。Objective To investigate the clinical feasibility of Xuebijing Injection combined with Ulinastatin Injection in the treatment of pyemia.Methods A total of 90 pyemia patients were selected as research objects,they were divided into observation group and control group according to different treatment methods,45 cases in each group.The observation group was given Xuebijing Injection combined with Ulinastatin Injection for treatment,the control group was given Xuebijing Injection for treatment alone.The curative effect,mechanical ventilation time,length of stay,white blood cell count,C reactive protein,sequential organ failure assessment(SOFA)score before and after treatment,complications between the two groups were compared.Results After treatment,the total effective rate of the observation group was 84.44%,which was significantly higher than 66.67%of the control group,the difference was statistically significant(P<0.05).The mechanical ventilation time and length of stay in the observation group were(10.51±1.31)d and(13.51±2.11)d respectively,which were significantly shorter than(14.29±2.27)d and(18.49±3.04)d in the control group,the differences were statistically significant(P<0.05).The white blood cell count,C reactive protein and SOFA score of the observation group were(6.71±0.03)×109/L,(22.62±0.15)mg/L and(1.01±0.11)scores respectively,which were significantly better than(11.29±0.13)×109/L,(52.41±0.20)mg/L and(2.01±0.11)scores of the control group,the differences were statistically significant(P<0.05).No complications occurred in the two groups.Conclusion The effect of Xuebijing Injection combined with Ulinastatin Injection in the treatment of pyemia is reliable,can effectively improve the clinical symptoms,reduce inflammation levels,safe and effective,is worthy of popularization and application.

关 键 词：血必净注射液 乌司他丁注射液 脓毒血症 可行性 

分 类 号：R459.7[医药卫生—急诊医学]