高血流量与高透析液流量透析对维持性血液透析患者微炎症状态及营养状况的影响  

Effect of high blood flow and high dialysate flow dialysis on microinflammation and nutritional status in maintenance hemodialysis patients

作　　者：赵立琳 赵文 李双飞 ZHAO Lilin;ZHAO Wen;LI Shuangfei(Department of Nephrology,Second People′s Hospital of Futian District,Shenzhen,518049,China)

机构地区：[1]深圳市福田区第二人民医院肾内科,深圳市518049

出　　处：《内科》2018年第5期698-700,共3页Internal Medicine

基　　金：深圳市福田区卫生公益性科研项目(FTWS2014050)

摘　　要：目的探讨高血流量及高透析液流量透析对维持性血液透析患者微炎症状态以及营养状况的影响。方法选取2014年6～12月在我院血液净化中心进行维持性血液透析的患者80例为研究对象,采用随机数表法分为两组,每组40例。对照组患者给予常规血流量、常规透析液流量透析治疗,设定血流量为250～300 m L/min,透析液流量为500 m L/min;观察组患者给予高血流量、高透析液流量透析治疗,设定血流量为300～350 m L/min,透析液流量为800 m L/min。比较两组患者的微炎症状态及营养状况。结果治疗1个月和6个月后,两组患者TNF-α、IL-6、hs-CRP水平均显著下降,观察组的TNF-α、IL-6、hs-CRP水平均显著低于对照组,差异有统计学意义(P <0. 05);两组患者血清白蛋白(ALB)、总蛋白(TP)、血红蛋白(Hb)水平均显著上升,观察组患者ALB、TP、Hb水平均显著高于对照组,差异有统计学意义(P <0. 05)。结论高血流量与高透析液流量透析治疗能更有效地改善维持性血液透析患者的微炎症状态及营养状况,提高临床治疗效果。Objective To investigate the effects of high blood flow and high dialysate flow dialysis on microinflammation and nutritional status in maintenance hemodialysis patients.Methods 80 patients who underwent maintenance hemodialysis in our hospital′s blood purification center from June 2014 to December 2014 were enrolled in the study.They were randomly divided into two groups,40 in each group.The control group were given routine blood flow and conventional dialysate flow dialysis treatment.The blood flow was set to 250-300 mL/min,and the dialysate flow was set to 500 mL/min.The observation group were given high blood flow and high dialysate flow dialysis treatment.The blood flow was set to 300-350 mL/min,and the dialysate flow was set to 800 mL/min.The microinflammation status and nutritional status of the two groups were compared.Results After 1 month and 6 months of treatment,the levels of TNF-α,IL-6 and hs-CRP in the two groups were significantly decreased.The levels of TNF-α,IL-6 and hs-CRP in the observation group were significantly lower than those in the control group.The difference was statistically significant(P<0.05).The levels of serum albumin(ALB),total protein(TP)and hemoglobin(Hb)in the two groups were significantly increased.The ALB,TP and Hb levels in the observation group were significantly higher than those in the control group(P<0.05).Conclusion High blood flow and high dialysate flow dialysis treatment can effectively improve the microinflammatory state and nutritional status of maintenance hemodialysis patients,and improve the clinical treatment effect.

关 键 词：血液透析 高血流量 高透析液流量 微炎症状态 营养不良 

分 类 号：R59[医药卫生—内科学]