丙戊酸钠与左乙拉西坦治疗小儿癫痫的疗效及安全性比较  

Comparison of efficacy and safety of valproate and levetiracetam in treatment of children with epilepsy

作　　者：严建华 唐尚鸿[1] 张秀琴[1] YAN Jianhua;TANG Shanghong;ZHANG Xiuqin(Department of Pediatric,Huizhou Central People′s Hospital,Huizhou 516000,Guangdong,China)

机构地区：[1]惠州市中心人民医院儿科,广东省惠州市516000

出　　处：《内科》2018年第5期750-752,共3页Internal Medicine

摘　　要：目的比较丙戊酸钠与左乙拉西坦治疗小儿癫痫的临床效果及安全性。方法选取2015年10月至2017年10月在我院诊治的癫痫患儿72例,依据随机数字表法分为A组和B组,每组36例。A组患儿给予丙戊酸钠治疗,B组患儿给予左乙拉西坦治疗。治疗2个月后比较两组患儿的临床疗效、痫样放电好转率、血钙血磷水平、认知功能以及不良反应发生率。结果治疗2个月后,B组患儿的痫样放电好转率(91. 67%)显著高于A组(72. 22%),血钙血磷水平显著低于A组,语言智商、操作智商及总智商评分均优于A组,差异有统计学意义(P <0. 05);两组患儿的治疗总有效率及不良反应发生率比较,差异无统计学意义(P> 0. 05)。结论丙戊酸钠与左乙拉西坦治疗癫痫患儿临床疗效相当,二者均具有较高的治疗安全性;但左乙拉西坦治疗对改善患儿脑电、血钙、血磷水平及认知功能的效果优于丙戊酸钠治疗。Objective To compare the efficacy and safety of valproate and levetiracetam in the treatment of pediatric epilepsy.Methods 72 cases of epileptic children treated in our hospital from October 2015 to October 2017 were selected and randomly divided into group A and group B,with 36 cases in each group.Group A were treated with valproate and group B were treated with levetiracetam.After 2 months of treatment,the clinical efficacy,improvement rate of epileptiform discharge,the levels of serum calcium and phosphorus,cognitive function and incidence of adverse reactions were compared between the two groups.Results After 2 months of treatment,the improvement rate of epileptiform discharge in group B(91.67%)was significantly higher than that in group A(72.22%),the levels of blood calcium and phosphorus were significantly lower than that of group A;the scores of language IQ,operational IQ and total IQ in group B were obviously superior to that of group A(P<0.05).The total effective rate and adverse reactions rate were compared between the two groups,the differences were not statistically significant(P>0.05).Conclusion The valproate and levetiracetam in treatment of children with epilepsy both are remarkable and safety,but levetiracetam is more beneficial to EEG,the levels of blood calcium and phosphorus,and cognitive function for children with epilepsy.

关 键 词：癫痫 儿童 丙戊酸钠 左乙拉西坦 不良反应 

分 类 号：R59[医药卫生—内科学]