纤维介素2在慢性病毒性肝炎患者中的表达水平及临床意义  

The expression and clinical significance of soluble fibrinogen-like protein 2 in patients with chronic viral hepatitis

作　　者：陈云茹[1] 孙阳阳[2] 邸莹[3] 唐甜甜 杨雪亮[1] 张曦[1] 刘小静[1] 叶峰[1] 蔺淑梅[1] CHEN Yun-ru;SUN Yang-yang;DI Ying;TANG Tian-tian;YANG Xue-liang;ZHANG Xi;LIU Xiao-jing;YE Feng;LIN Shu-mei(Department of Infectious Diseases,The First Affiliated Hospital of Xi an Jiaotong University,Xi an 710061;Department of Pharmacy,No.1 Hospital of PLA,Lanzhou 730000;Department of Hepatobiliary Surgery,The First Affiliated Hospital of Xi an Jiaotong University,Xi an 710061;Department of Infectious Diseases,Xi an Children s Hospital,Xi an 710003,China)

机构地区：[1]西安交通大学第一附属医院感染科,陕西西安710061 [2]中国解放军第一医院药剂科,甘肃兰州730000 [3]西安交通大学第一附属医院肝胆外科,陕西西安710061 [4]西安市儿童医院感染科,陕西西安710003

出　　处：《西安交通大学学报（医学版）》2018年第6期876-879,884,共5页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：国家"十三五"重大传染病防治科技重大专项(No.2017ZX10201201)~~

摘　　要：目的探讨可溶性纤维介素2(sFgl2)检测对预测慢性病毒性肝炎患者临床转归和预后的价值。方法采用ELISA法分别检测85例慢性肝炎患者(42例乙型肝炎和43例丙型肝炎)、108例肝硬化患者(35例乙型肝炎和73例丙型肝炎)及72例健康对照者外周血sFgl2的水平,并与Child-Pugh分级及肝功能指标进行Spearman相关性分析。结果血清sFgl2水平在肝硬化组显著高于非肝硬化组及健康对照组,且在肝硬化患者中,随Child-Pugh评分升高,外周血sFgl2水平逐渐升高。Spearman相关性分析显示,不考虑病原学,sFgl2水平与TBIL呈正相关,与ALB呈负相关。但与病毒载量、ALT或AST无相关性。结论证实了外周血sFgl2在肝硬化患者中明显升高,同时发现sFgl2水平与肝硬化患者Child-Pugh分级呈正相关,提示sFgl2水平与肝病严重程度相关,可能成为评估肝硬化患者预后的因素之一。Objective To explore the value of soluble fibrinogen-like protein 2(sFgl2)assay in predicting clinical outcome and prognosis in patients with chronic viral hepatitis.Methods The level of sFgl2 in serum was tested by ELISA method in 85 patients with chronic hepatitis(42 cases of hepatitis B and 43 ones of hepatitis C),108 liver cirrhosis patients(35 cases of hepatitis B and 73 ones of hepatitis C),and 72 healthy controls.Spearman correlation was analyzed between sFgl2 level and liver function or Child-Pugh classification.Results The sFgl2 level was significantly higher in liver cirrhosis group than in chronic hepatitis group and healthy controls.As the Child-Pugh score increased,the sFgl2 level of liver cirrhosis patients increased gradually.Regardless of the etiology,the positive relation between sFgl2 with TBIL and negative relation between sFgl2 with ALB could be detected.However,sFgl2 level did not have correlation with viral load or the level of ALT or AST.Conclusion The study further confirmed that serum sFgl2 was significantly elevated in patients with liver cirrhosis and that sFgl2 level was positively correlated with Child-Pugh score.It suggests that sFgl2 level is related to the severity of cirrhosis and may become a tool to evaluate the prognosis of cirrhosis.

关 键 词：可溶性纤维介素2 肝硬化 丙型肝炎病毒 乙型肝炎病毒 

分 类 号：R512.6[医药卫生—内科学]