血浆同型半胱氨酸水平在绝经期妇女中的价值分析  

The value of plasma homocysteine level in menopausal women

作　　者：王斌[1] 宁宜国 张鸿艳[1] 张露 王莉 刘琰 黄勇进[1] 范敬东[1] Wang Bin;Ning Yiguo;Zhang Hongyan(Hubei Aerospace Hospital,Xiaogan 432000)

机构地区：[1]湖北航天医院,湖北孝感432000

出　　处：《中国现代医药杂志》2018年第10期4-7,共4页Modern Medicine Journal of China

基　　金：中国航天科工集团公司2016年医疗卫生科研项目(编号:2016-LCYL-018)

摘　　要：目的探讨血浆同型半胱氨酸(Homocysteine,Hcy)水平在绝经期妇女中的价值。方法选择2016年10月～2017年9月我院健康体检人群2 033例,测定血浆Hcy水平。相关性分析采用Spearman检验。Logistic回归分析计算血浆Hcy水平预测心血管疾病的比值比(odds ratio,OR)和95%置信区间(confidence interval,CI)。结果绝经前期、围绝经期和绝经期研究对象血浆Hcy水平分别为(7.5±0.5)μmol/L、(7.7±0.6)μmol/L和(9.1±0.8)μmol/L。单因素方差分析显示,三组间血浆Hcy水平差异显著(P=0.035)。两两比较结果显示,绝经前期和围绝经期组的血浆Hcy水平均低于绝经期组,且差异具有统计学意义(P<0.05),而绝经前期和围绝经期两组之间差异无统计学意义(P>0.05)。绝经期女性血浆Hcy水平与年龄(R2=0.297,P<0.001)、冠心病史(R2=0.289,P<0.001)和脑梗死史(R2=0.304,P<0.001)呈线性关联。多因素分析显示,在校正年龄、吸烟史、饮酒史等因素影响后,血浆高Hcy水平和高血脂仍是女性心脑血管发病的独立危险因素(P<0.05)。结论血浆Hcy可预测绝经后妇女患心血管病的风险,以此进行早期健康指导和临床干预对提高绝经后妇女的生活质量具有重要意义。Objective To investigate the value of plasma homocysteine(Hcy)in menopausal women.Methods A total of 2 033 healthy people in our hospital from Oct 2016 to Sep 2017 were selected to measure the levels of plasma Hcy.Spearman test was used for the correlation analysis.Logistic regression analysis was used to calculate the value of plasma Hcy level for the odds rati(o OR)and the 95%confidence interva(l CI)of cardiovascular disease.Results The plasma Hcy levels in premenopausal,perimenopausal and menopausal subjects were(7.5±0.5)μmol/L,(7.7±0.6)μmol/L and(9.1±0.8)μmol/L,respectively.Single factor analysis of variance showed that there were significant differences in plasma Hcy level among the three groups(P=0.035).Further comparative results showed that plasma Hcy levels in premenopausal and perimenopausal women were lower than those in the menopausal group,and the differences were statistically significan(t P<0.05).There was no significant difference between the two groups in premenopausal and perimenopausal period(P>0.05).The levels of plasma Hcy in menopausal women were linearly correlated with age(R^2=0.297,P<0.001),coronary heart disease(R^2=0.289,P<0.001)and cerebral infarction(R^2=0.304,P<0.001).Multivariate analysis showed that high plasma Hcy and hyperlipidemia were independent risk factors(P<0.05)in women's cardiovascular and cerebrovascular disease after correction of age,smoking history,drinking history and other factors.Conclusion Hcy can predict the risk of cardiovascular disease in postmenopausal women.Early health guidance and clinical intervention are important to improve the quality of life of postmenopausal women.

关 键 词：同型半胱氨酸 绝经期妇女 心血管疾病 

分 类 号：R173[医药卫生—妇幼卫生保健] R446.1[医药卫生—公共卫生与预防医学]