血栓形成前状态分子标志物变化在不稳定性心绞痛合并糖尿病患者中的意义  

Significance of changes of pre-thrombosis molecular markers in patients with unstable angina pectoris complicated by diabetes mellitus

作　　者：马建林[1] 马向杰[1] 周燕[1] 马立宁[1] 张家明[2] 李大主 林劲[1] 张敬文[1] 王圣[1] 李斌[1] Ma Jianlin;Ma Xiangjie;Zhou Yan;Ma Lining;Zhang Jiaming;Li Dazhu;Lin Jin;Zhang Jingwen;Wang Sheng;Li Bin(Department of Cardiology,People's Hospital of Hainan Province,Haikou 570311,China)

机构地区：[1]海南省人民医院心内科,海口570311 [2]华中科技大学同济医学院附属协和医院心内科,武汉430022

出　　处：《中国循证心血管医学杂志》2018年第10期1205-1207,共3页Chinese Journal of Evidence-Based Cardiovascular Medicine

基　　金：海南省自然科学基金自助项目(20158328)

摘　　要：目的观察不稳定性心绞痛(UAP)合并糖尿病(DM)患者体内血栓形成前状态分子标志物水平的变化及临床意义。方法随机选择2015年1月～2016年9月于海南省人民医院住院的40例UAP合并DM患者(合并症组),40例UAP患者(UAP组),40例健康对照者(对照组)。分别测定各组体内假性血友病因子(vWF)、纤溶酶原(Plg)、抗凝血酶Ⅲ(ATⅢ)、Ⅷ因子相关抗原(Ⅷ:Ag)、血小板颗粒膜蛋白-140(GMP-140),蛋白C(PC),Ⅱ因子活性(FⅡa)、组织型纤溶酶原激活物(t-PA)、组织型纤溶酶原激活物抑制剂(PAI)、D-二聚体(D-dimer)、血栓素B2(TXB2)。结果合并症组vWF,Ⅷ:Ag,GMP-140,FⅡa,PAI-1,D-Dimer,TXB2水平与UAP组以及对照组相比,明显升高(P<0.05),而ATⅢ,PC,t-PA水平与UAP组以及对照组相比,明显降低(P<0.05);UAP组vWF,Ⅷ:Ag,GMP-140,FⅡa,PAI-1,D-Dimer,TXB2水平与对照组相比,明显升高(P<0.05),而UAP组ATⅢ,PC,t-PA水平与对照组相比,明显降低,差异具有统计学意义(P<0.05)。结论 UAP合并DM患者体内存在更明显的止凝血分子标志物水平的变化,可能是影响其预后不良的重要因素。Objective To observe the changes and clinical significance of pre-thrombosis molecular markers in patients with unstable angina pectoris(UAP)complicated by diabetes mellitus(DM).Methods The patients with UAP complicated by DM(n=40,complication group),UAP patients(n=40,UAP group)and health controls(n=40,control group)were chosen from People’s Hospital of Hainan Province from Jan 2015 to Sep 2016.The levels of von Willebrand factor(vWF),plasminogen(Plg),antithrombinⅢ(ATⅢ),factor VⅢrelated antigen(VⅢ:Ag),platelet membrane glycoprotein-140(GMP-140),protein C(PC),factorⅡactivity(FⅡa),tissue plasminogen activator(t-PA),plasminogen activator inhibitor(PAI),D-dimer(DD)and thromboxane B2(TXB2)were detected in all groups.Results The levels of vWF,Ⅷ:Ag,GMP-140,FⅡa,PAI-1,D-Dimer and TXB2 increased significantly(P<0.05),and levels of ATⅢ,PC and t-PA decreased significantly(P<0.05)in complication group compared with UAP group and control group.The levels of vWF,Ⅷ:Ag,GMP-140,FⅡa,PAI-1,D-Dimer and TXB2 increased significantly(P<0.05),and levels of ATⅢ,PC and t-PA decreased significantly(P<0.05)in UAP group compared with control group.Conclusion The levels of hemostasis-coagulation molecular markers have significant changes in patients with UAP complicated by DM,which are important factors influencing patients’prognosis.

关 键 词：不稳定性心绞痛 糖尿病 血栓形成前状态分子标志物 

分 类 号：R541.4[医药卫生—心血管疾病]