急性ST段抬高型心肌梗死尿激酶原(普佑克)时间窗内溶栓疗效观察  

Clinical thrombolytic effect observation of urokinase(Pu Yu Ke) in the treatment of patients with acute ST segment elevation myocardial infarction in time window

作　　者：黄丽娟[1] 黄慧敏 Huang Lijuan;Huang Huimin(The People's Hospital of Guidong County in Hunan Province,Hunan Chenzhou 423500;The Second Hospital of Xiangya in Central South University,Hunan Changsha 410011)

机构地区：[1]湖南省桂东县人民医院,湖南长沙423500 [2]中南大学湘雅二医院,湖南郴州410011

出　　处：《中国社区医师》2018年第31期17-18,20,共3页Chinese Community Doctors

摘　　要：目的:探讨急性ST段抬高型心肌梗死(STEMI)尿激酶原(rhPro-UK,普佑克)时间窗内溶栓疗效。方法:收治STEMI患者94例,随机分为两组,每组各47例。对照组给予UK溶栓,观察组给予rhPro-UK溶栓,比较两组治疗效果。结果:观察组溶栓后2 h冠脉再通率高于对照组,MACE发生率明显低于对照组,差异有统计学意义(P<0.05)。溶栓后2 h,观察组D-D水平低于对照组,FIB水平高于对照组,差异有统计学意义(P<0.05)。结论:rhPro-UK治疗STEMI溶栓效果良好,可有效促进冠脉再通,改善心肌血液灌注。Objective:To investigate the thrombolytic effect of urokinase(rhPro-UK,Pu Yu Ke)in the time window of acute ST segment elevation myocardial infarction(STEMI).Methods:94 cases of patients with STEMI were divided into two groups randomly.The control group was given UK thrombolysis,the observation group was given rhPro-UK thrombolysis,and the clinical effect of the two groups was compared.Results:The recanalization rate of the 2 h after thrombolysis in the observation group was higher than that in the control group,and the incidence of MACE was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).At 2 h after thrombolysis,the level of D-D in the observation group was lower than that in the control group,and the level of FIB was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:RhPro-UK was effective in thrombolytic therapy of STEMI,which could promote coronary recanalization and improve the myocardial blood perfusion effectively.

关 键 词：急性ST段抬高型 心肌梗死 时间窗 注射用重组人尿激酶原 溶栓 

分 类 号：R542.22[医药卫生—心血管疾病]