神经营养因子介导运动的抗抑郁作用  

Mediating Mechanism of Neurotrophic Factors in Antidepressant Effects of Exercise

作　　者：刘文彬[1,2] 刘微娜 漆正堂[1,2] LIU Wen-bin;LIU Wei-na;QI Zheng-tang(Key Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education,East China Normal University,Shanghai 200241,China;School of Physical Education and Health Care,East China Normal University,Shanghai 200241,China)

机构地区：[1]华东师范大学"青少年健康评价与运动干预"教育部重点实验室,上海200241 [2]华东师范大学体育与健康学院,上海200241

出　　处：《体育科学》2018年第10期54-66,共13页China Sport Science

基　　金：国家自然科学基金资助项目(31871208);上海市自然科学基金资助项目(18ZR1412000);中央高校基本科研业务费专项资金资助项目(2017ECNU-HWFW026);"青少年健康评价与运动干预"教育部重点实验室建设项目(40500-541235-14203/004)

摘　　要：神经营养因子是对神经元的发育、存活及凋亡发挥作用的蛋白质,因其在神经发育和神经可塑性中扮演的重要角色而备受神经科学领域的关注。抑郁的神经营养假说认为,抑郁会引起神经营养因子表达水平的改变,抑郁症患者多种神经营养因子的血清水平和脑区表达较健康人有明显差异,提示,神经营养因子可能成为新型抑郁症标志物。运动可通过改变多种神经营养因子的表达水平,包括神经生长因子基因家族、成纤维细胞生长因子家族、生神经细胞因子家族、胶质细胞源性神经营养因子家族以及血管内皮生长因子和胰岛素样生长因子-1等其他神经营养因子,进而调控神经可塑性、神经发生、细胞存活、下丘脑-垂体-肾上腺轴活性、单胺类神经递质、中枢炎症等,从而发挥其抗抑郁作用。梳理神经营养因子介导运动抗抑郁的可能机制,这将有助于筛选出"外周营养因子"作为抑郁症液体活检、运动干预的生物标记,为抑郁症的研究和治疗提供更多可能性。Neurotrophic factors play a role in the development,survival and apoptosis of neurons,because of its important role in the neurodevelopment and neuroplasticity,it has long been paid much attention in the field of neuroscience.The neurotrophic hypothesis of depression believed that depression can lead to changes in the expression level of neurotrophic factors,the serum level and brain region expression of various neurotrophic factors in patients with depression are significantly different from the healthy individuals,this suggests that neurotrophic factors may become a new marker of depression.Exercise can regulate neuroplasticity,neurogenesis,cell survival,hypothalamicpituitary-adrenal axis activity,monoamine neurotransmitters,central inflammation and then play antidepressant effects by changing the expression level of many neurotrophic factors,including nerve growth factor gene family,fibroblast growth factor family,neuropoietic cytokine family,glial cell linederived neurotrophic factor family and other neurotrophic factors such as vascular endothelial growth factor and insulin like growth factor-1.This paper reviews mediating mechanism of neurotrophic factors in antidepressant effects of exercise,we hope to find“peripheral neurotrophic factors”as depression biomarkers used for biopsy and exercise intervention,and the findings are supposed to suggest more possibilities for research and treatment of depression.

关 键 词：神经营养因子 抑郁 运动干预 介导机制 

分 类 号：G804.5[文化科学—运动人体科学]