血清高密度脂蛋白不同组分与冠状动脉病变的相关性研究  

Association between components of serum high density lipoprotein and coronary heart disease

作　　者：李丽君[1] 王晶[1] 穆洋[1] 徐勇[1] LI Li-jun;WANG Jing;MU Yang;XU Yong(Dept.of Cardiology,Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]中国人民解放军总医院心内科,北京100853

出　　处：《基础医学与临床》2018年第11期1558-1562,共5页Basic and Clinical Medicine

摘　　要：目的观察高密度脂蛋白胆固醇(HDL-C)及载脂蛋白AI水平与冠状动脉病变(CHD)之间的关系。方法入选208例接受冠脉造影的患者,应用酶比色法检测血浆Apo A-Ⅰ和HDL-C含量以及其他与冠心病(CHD)相关的指标,同时根据冠脉病变支数和Gesini评分对这些患者的冠脉病变程度进行定性和定量分析。比较冠心病组和非冠心病组患者HDL-C和Apo A-Ⅰ水平及相关指标的差异。采用Logistic和多重回归的方法分析影响冠脉病变发生和病变程度的因素。结果冠心病组患者血浆Apo A-Ⅰ和HDL-C水平显著低于对照组(P<0. 05); Apo A-Ⅰ水平与CHD发生负相关(P<0. 015); Apo A-Ⅰ水平与CHD病变程度负相关(P<0. 05)。结论 Apo A-Ⅰ,而非HDL-C与CHD发生及病变程度显著负相关。Objective To investigate the association between HDL and CHD.Methods Two hundred and eight consecutive patients who underwent angiography were enrolled into this project.Plasma ApoA-Ⅰand HDL-C were measured in all patients.Angiography analysis included number of lesions and gensini score as qualitative and quantitaive measurements.Clinical and HDL level were compared between patients with CHD and patients without CHD.Logistic regression analysis was used to assess independent predictors for presence of CHD and CHD extent.Results The concentrations of plasma ApoA-Ⅰ(P<0.015)were significantly lower in the CHD group than non-CHD group.The concentation of ApoA-Ⅰwas found to be significant predictors of presence of CHD(P<0.015).The concentrations of ApoA-Ⅰdecresead with the increase on vascular damage(P<0.015).Conclusions The concentration of ApoA-Ⅰis independenty negative related with the presence of CHD and CHD extent.

关 键 词：高密度脂蛋白胆固醇 载脂蛋白AI 冠心病 

分 类 号：R44[医药卫生—诊断学]